{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:52:05Z","timestamp":1785365525920,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n NUP98<\/jats:italic>\n ::\n BPTF<\/jats:italic>\n rearranged (r) leukaemia is rare with only five reported cases, including acute myeloid leukemia and T\u2010lymphoblastic leukemia (T\u2010ALL).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Herein, we report a case of\n NUP98::BPTF<\/jats:italic>\n \u2010r mixed phenotype acute leukemia (MPAL), B\/T with T\u2010lineage\u2010predominance in a 15\u2010year\u2010old female. Cytogenetic and molecular studies revealed a t(11;17)(p15;q23)\/\n NUP98::BPTF<\/jats:italic>\n fusion and cooperative gene alterations characteristic of T\u2010ALL (\n NOTCH1<\/jats:italic>\n ,\n FBXW7<\/jats:italic>\n , and\n PHF6<\/jats:italic>\n ). Our patient had a primary induction failure with T\u2010ALL\u2010directed chemotherapy and achieved complete remission following consolidation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the first case study characterizing the clinicopathological and genomic features of B\/T MPAL harboring\n NUP98::BPTF<\/jats:italic>\n fusion and providing insights into molecular pathogenesis.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70166","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T14:38:05Z","timestamp":1760452685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["B\/T Mixed Phenotype Acute Leukaemia Harbouring\n NUP98::BPTF<\/i>\n Fusion"],"prefix":"10.1002","volume":"6","author":[{"given":"Van Tuong","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cantu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Fuda","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"John","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamra","family":"Slone","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001613\u20101"},{"issue":"18","key":"e_1_2_11_3_1","first-page":"2275","article-title":"The International Consensus Classification of Acute Leukemias of Ambiguous Lineage","volume":"141","author":"Weinberg O. 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