{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:54:49Z","timestamp":1766987689795,"version":"3.48.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n DDX3X:\n :MLLT10<\/jats:italic>\n \u00b8 which arises from t(X;10)(p11.4;p12.31), is infrequently observed in adult acute myeloid leukaemia (AML). The clinical and pathological characteristics are also not well characterised, detailed in only two cases published to date. This third case reports the fusion gene in a 27\u2010year\u2010old female with acute myelomonocytic leukaemia (AMML) with refractoriness to multiple lines of chemotherapy. Collectively, these cases highlight the genomic heterogeneity of this rare entity, as well as significant unmet clinical needs due to the poor prognosis and chemoresistance observed. These findings may inform future iterations of AML classification and prognostication in adults.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70181","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:33:31Z","timestamp":1765377211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult Acute Myeloid Leukaemia With\n DDX3X::MLLT10<\/i>\n : A Rare Entity With Significant Unmet Clinical Needs"],"prefix":"10.1002","volume":"6","author":[{"given":"Jun Yen","family":"Ng","sequence":"first","affiliation":[{"name":"School of Medicine and Psychology College of Science and Medicine Australian National University Canberra Australia"},{"name":"Department of Haematology Canberra Hospital Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"SR","sequence":"additional","affiliation":[{"name":"Department of Haematology Canberra Hospital Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maansi","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Haematology Canberra Hospital Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Talaulikar","sequence":"additional","affiliation":[{"name":"School of Medicine and Psychology College of Science and Medicine Australian National University Canberra Australia"},{"name":"Department of Haematology Canberra Hospital Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22887"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010805"},{"volume-title":"WHO Classification of Tumours Series","year":"2024","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_11_4_1"},{"volume-title":"ISCN 2020\u00a0: An International System for Human Cytogenomic Nomenclature","year":"2020","author":"International Standing Committee on Human Cytogenomic Nomenclature","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_11_7_1","unstructured":"J. W.Wittwer \u201cExcel Timeline Templates \u201d Vertex42.com 2020 https:\/\/www.vertex42.com\/ExcelTemplates\/timeline.html."},{"key":"e_1_2_11_8_1","unstructured":"T.Gindina \u201ct(X;10)(p11;p12) DDX3X\/MLLT10 \u201dAtlas Genet Cytogenet Oncol Haematol published October 1 2016 https:\/\/atlasgeneticsoncology.org\/haematological\/1701\/t(x;10)(p11;p12)\u2010ddx3x\u2010mllt10."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.06.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.959243"},{"journal-title":"Cytometry Part B: Clinical Cytometry","article-title":"An Uncommon Case of Acute Megakaryoblastic Leukemia With DDX3X::MLLT10 Fusion Gene","author":"Li T.","key":"e_1_2_11_11_1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9908-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.101725"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.09.026"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:52:34Z","timestamp":1766987554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jha2.70181"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70181","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70181"}}