{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:26:57Z","timestamp":1784579217288,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      5\u2010Azacitidine (AZA) is a major treatment option for myelodysplastic neoplasms (MDS) and myelodysplastic\/myeloproliferative neoplasms (MDS\/MPN). Here we evaluate the efficacy and toxicity of an alternative AZA regimen (100\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day for 5 days\/28 days) in 68 patients (51 MDS, 17 MDS\/MPN) treated between 2008 and 2018.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median patient age was 66 years, with most patients (98%) having intermediate or high\u2010risk disease. Overall response rate (ORR) was 62% with 22% complete responses (CR). Median OS and median PFS were 22.5 and 18.2 months, respectively. Inferior response rates were calculated in therapy\u2010related MDS (t\u2010MDS) and MDS with excess blast II, with t\u2010MDS having also statistically worse OS and PFS. MDS\/MPN patients showed 73.6% ORR with 31.5% CR. Transfusion independence (TI) for red blood cells (RBC) was achieved in 45.9% of transfusion\u2010dependent patients and in 30% for platelets. CR patients showed longer mOS and mPFS (70.6 and 64.7 months, respectively). Longer mOS was also correlated with allogeneic transplantation (48.8 vs. 16.9 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and RBC TI (25.4\u00a0vs. 13.3 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Grade 3\/4 cytopenias occurred in 41.1% (neutropenia in 33.8%), and treatment\u2010related mortality was 7.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that this alternative AZA regimen has comparable efficacy and safety to the standard regimen, compared with historical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70185","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:30:20Z","timestamp":1764163820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alternative 5\u2010Azacitidine 5\u2010Day 100\u00a0mg\/m\n                    <sup>2<\/sup>\n                    Dosage Shows Non\u2010Inferiority to Classical Schedule for Myelodysplastic Neoplasm (MDS) and Chronic Myelomonocytic Leukaemia (CMML) Treatment"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-8420","authenticated-orcid":false,"given":"Gerasimos","family":"Tsilimidos","sequence":"first","affiliation":[{"name":"Hematology Service and Central Laboratory of Hematology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Martins","sequence":"additional","affiliation":[{"name":"Clinics of Medical Oncology Cantonal Hospital of Fribourg (HFR)  Fribourg Switzerland"},{"name":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-9886","authenticated-orcid":false,"given":"Mariangela","family":"Costanza","sequence":"additional","affiliation":[{"name":"Hematology Service and Central Laboratory of Hematology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-8197","authenticated-orcid":false,"given":"Mathilde","family":"Gavillet","sequence":"additional","affiliation":[{"name":"Hematology Service and Central Laboratory of Hematology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Blum","sequence":"additional","affiliation":[{"name":"Hematology Service and Central Laboratory of Hematology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02135399"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001218\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205699"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23607"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V48.3.331.331"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"21","article-title":"Effects of Treatment With 5\u2010Azacytidine on the In Vivo and In Vitro Hematopoiesis in Patients With Myelodysplastic Syndromes","volume":"7","author":"Silverman L. 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