{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:54:36Z","timestamp":1766987676965,"version":"3.48.0"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy is a highly effective treatment for relapsed or refractory large B\u2010cell lymphoma (LBCL), but clinical experience in people living with HIV (PLWH) remains limited due to their exclusion from pivotal trials. We report the case of a 55\u2010year\u2010old man with HIV and high\u2010grade B\u2010cell lymphoma who developed severe anaphylaxis during axicabtagene ciloleucel (axi\u2010cel) infusion, requiring early termination after approximately 50% of the planned dose was delivered. The patient experienced only Grade 1 cytokine release syndrome and no neurotoxicity. Despite incomplete infusion, he achieved a sustained partial metabolic response on PET\/CT imaging at Days +30, +60, and +110 post\u2010infusion. HIV remained well\u2010controlled throughout, and no infectious complications were observed. This case highlights both the feasibility of administering CAR T\u2010cell therapy in virologically suppressed PLWH and the potential for clinical benefit even with partial cell delivery. In addition, it draws attention to anaphylaxis as a rare but serious infusion\u2010related adverse event. To our knowledge, this is the first report of anaphylaxis to axi\u2010cel in a PLWH. The case underscores the need for enhanced pharmacovigilance and pre\u2010infusion risk assessment. It also supports growing evidence that PLWH should not be categorically excluded from CAR T\u2010cell access or clinical trials.<\/jats:p>","DOI":"10.1002\/jha2.70190","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:21:16Z","timestamp":1764163276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anaphylaxis During CAR T\u2010Cell Infusion in an HIV\u2010Positive Patient With High\u2010Grade B\u2010Cell Lymphoma: A Case Report and Literature Review"],"prefix":"10.1002","volume":"6","author":[{"given":"Mostafa F. Mohammed","family":"Saleh","sequence":"first","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-810X","authenticated-orcid":false,"given":"Abdulrahman","family":"Nasiri","sequence":"additional","affiliation":[{"name":"College of Medicine Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Alsuhaibani","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawaf","family":"Aldawsari","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeel","family":"Samrkandi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy King Faisal Specialist Hospital &amp; Research Centre  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naeem","family":"Chaudhri","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed O","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Aljurf","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfadel","family":"Alshaibani","sequence":"additional","affiliation":[{"name":"Adult Hematology Stem Cell Transplant and Cellular Therapy Department Oncology Center King Faisal Specialist Hospital and Research Center  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1016\/S1470\u20102045(21)00591\u2010X"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1056\/NEJMoa2116133"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1111\/hiv.13514"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1182\/blood\u20102024\u2010205388"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1097\/01.cco.0000172824.78318.b9"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1158\/2326\u20106066.cir\u201013\u20100006"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:51:47Z","timestamp":1766987507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jha2.70190"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70190","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70190"}}