{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:54:41Z","timestamp":1766987681858,"version":"3.48.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple myeloma (MM) is a genetically heterogeneous malignancy in which cytogenetic abnormalities critically influence prognosis. The prognostic significance of 17p gain\/amplification (17p+), particularly relative to del(17p) and the high\u2010risk 1q21 gain\/amplification (1q21+), remains insufficiently defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 125\u00a0MM patients treated at a single center between 2015 and 2024. Cytogenetic profiles were assessed using fluorescence in situ hybridization (FISH). Kaplan\u2013Meier curves and Cox proportional hazards models evaluated the impact of 17p+ on progression\u2010free survival 1 (PFS1), time to next treatment (TTNT), and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with del(17p), 17p+ was associated with significantly longer PFS1 (HR 0.21,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), TTNT (HR 0.18,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), and OS (HR 0.25,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In patients receiving proteasome inhibitor\u2013based therapy or not undergoing autologous stem cell transplantation, 17p+ remained favorable for PFS1 (HR 0.20,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05, HR 0.21,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Multivariate Cox models confirmed 17p+ as an independent protective factor for PFS1 (HR 0.08), TTNT (HR 0.07), and OS (HR 0.02) (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Among patients with 1q21+, co\u2010occurrence of 17p+ improved PFS1 (HR 0.47) and TTNT (HR 0.36) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), though no significant OS benefit was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>17p+ is associated with markedly improved clinical outcomes in MM and may partially mitigate the adverse prognostic impact of 1q21+. These findings highlight the relevance of 17p+ in cytogenetic risk stratification and personalized treatment strategies and support further validation in multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70195","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:35:13Z","timestamp":1765809313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gain\/Amplification 17p as a Potential Favorable Prognostic Factor in Multiple Myeloma: A Real\u2010World Settings Retrospective Study"],"prefix":"10.1002","volume":"6","author":[{"given":"Teng","family":"Wang","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-2388","authenticated-orcid":false,"given":"Siyuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Tang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-7907","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-1542","authenticated-orcid":false,"given":"Ruirong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology Health Commission of Shandong Province  Jinan China"},{"name":"Institute of Hematology Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Hematology Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan 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