{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:07:27Z","timestamp":1785150447089,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extranodal peripheral T\u2010cell lymphomas (PTCLs) comprise a diverse group of lymphomas whose real\u2010world presentation and course are infrequently studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical characteristics and survival outcomes of 50 patients at a tertiary cancer center in Singapore between 2002 and 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 26 males and 24 females, with a median age of 50 years (range 16\u201384 years). The 5\u2010year progression\u2010free survival (PFS) and overall survival (OS) were 20.2% and 66.6%, respectively. Male sex (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.03) and lack of complete response to initial treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) predicted poorer PFS. Age\u00a0&gt;\u00a060 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), nodal involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), gastrointestinal origin (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), &gt;\u00a01 extranodal site of involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), and International Prognostic Index score &gt;\u00a02 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) predicted poorer OS. We also studied two subtypes: subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07) and monomorphic epitheliotropic intestinal T\u2010cell lymphoma (MEITL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07). Patients with SPTCL had a median age of 29 years and presented with lesions mimicking reactive lymph nodes (43%), lipomas (29%), or erythema nodosum (14%); no mortality was noted in our series. Patients with MEITL had a median age of 68 years and presented with bowel emergencies including perforation (57%), bleeding (14%), and obstruction (14%); all patients progressed or relapsed, and 5 demised\u20143 with small bowel relapse, 2 with central nervous system relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study provides insights into extranodal PTCLs and serves to guide our management of these rare lymphomas.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : The authors have confirmed clinical trial registration is not needed for this submission\n                    <\/jats:p>\n                  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