{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:45:22Z","timestamp":1790019922974,"version":"4.0.1"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n IDH<\/jats:italic>\n mutations are found in 15%\u201320% of acute myeloid leukemia (AML). Recent evidence suggests that\n IDH<\/jats:italic>\n mutation subtypes may respond differently to intensive chemotherapy. We evaluated blast clearance patterns, remission outcomes, and overall survival (OS) in AML patients with\n IDH2<\/jats:italic>\n R140,\n IDH2<\/jats:italic>\n R172, and\n IDH1<\/jats:italic>\n R132 mutations to assess differences in treatment response.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively reviewed AML patients diagnosed at Mayo Clinic, Rochester (2016\u20132023) with NGS data and treated with intensive chemotherapy (7+3 or CPX\u2010351). Bone marrow blasts were assessed at diagnosis, mid\u2010induction, and end\u2010of\u2010cycle; blast clearance was defined as <\u00a05%. Composite remission (CRc) included CR\/CRi per ELN 2022.\n IDH2<\/jats:italic>\n responders were classified as early (after Cycle 1) or late (\u2265\u00a02 cycles). Blast reduction was calculated as log\n 10<\/jats:sub>\n (diagnosis blasts\/end\u2010induction blasts) and normalized per day. OS was measured from diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 381 patients, 31 had\n IDH2<\/jats:italic>\n mutations (23 R140, 8 R172) and eight had\n IDH1<\/jats:italic>\n R132. Baseline blasts were similar. Mid\u2010cycle blasts were lower in R140 versus R172 (4% vs. 10%), with higher clearance (68% vs. 38%). End\u2010induction blasts were lower in R140 versus R172 (2% vs. 4%) with higher clearance (100% vs. 75%).\n IDH1<\/jats:italic>\n and\n IDH2<\/jats:italic>\n showed similar clearance patterns. Log\n 10<\/jats:sub>\n analyses showed deeper and faster blast reduction in R140 versus R172, with comparable kinetics between\n IDH1<\/jats:italic>\n and\n IDH2<\/jats:italic>\n . OS did not differ across subtypes. Early CRc in\n IDH2<\/jats:italic>\n \u2010mutated patients was associated with numerically longer OS.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n IDH2<\/jats:italic>\n R140 demonstrated faster blast clearance than R172, while remission and survival were similar across\n IDH<\/jats:italic>\n subtypes.\n <\/jats:p>\n \n Trial Registration<\/jats:bold>\n : The authors have confirmed clinical trial registration is not needed for this submission.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70204","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:05:58Z","timestamp":1765803958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blast Clearance Dynamics and Time to Response Across\n IDH1\u2010<\/i>\n and\n IDH2<\/i>\n \u2010Mutated AML"],"prefix":"10.1002","volume":"6","author":[{"given":"Mohamad Sheikh","family":"Najeeb","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oudai","family":"Alkabbani","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"He","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Jevremovic","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasiya","family":"Matin","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Hefazi","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abishek","family":"Mangaonkar","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseema","family":"Gangat","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecila Y. Arana","family":"Yi","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Foran","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan B","family":"Alkhateeb","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebede","family":"Begna","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Kewan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine N.","family":"Saliba","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Al\u2010Kali","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24648"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.348"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.275"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.269"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024015324"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26848"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004934"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:52:23Z","timestamp":1766987543000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jha2.70204"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70204","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70204"}}