{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:24:25Z","timestamp":1786123465715,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder causing excessive inflammation and tissue damage. Lymphoma, especially T\u2010cell lymphoma, is the most common cause of HLH, while Multiple Myeloma (MM) is rarely associated. We present a 61\u2010year\u2010old man with spiking fevers, fatigue, and unintentional weight loss. The HLH was driven by two distinct malignant clones in his bone marrow: plasma cell neoplasm and B\u2010cell lymphoma. Patient failed initial therapy with steroids, anakinra, and chemotherapy. Tocilizumab use, on the other hand, led to an excellent clinical and laboratory response immediately. This is the first reported case of HLH associated with two hematological malignancies.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : The authors have confirmed clinical trial registration is not needed for this submission\n                  <\/jats:p>","DOI":"10.1002\/jha2.70210","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:40:47Z","timestamp":1769139647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemophagocytic Lymphohistiocytosis as First Manifestation of Dual B\u2010Cell Neoplasms: A Case Report of Co\u2010Existing Multiple Myeloma and B\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8176-2342","authenticated-orcid":false,"given":"Carla","family":"Romagnoli","sequence":"first","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lyubimova","sequence":"additional","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leily","family":"Santos\u2010Carrion","sequence":"additional","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferial","family":"Alloush","sequence":"additional","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vathany","family":"Sriganeshan","sequence":"additional","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Noboa","sequence":"additional","affiliation":[{"name":"Sociedad de Lucha contra el C\u00e1ncer  Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline C.","family":"Barrientos","sequence":"additional","affiliation":[{"name":"Mount Sinai Comprehensive Cancer Center  Miami Beach, Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.975"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022299"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017005561"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30826"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02135-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.08.017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2436037"},{"issue":"9","key":"e_1_2_10_9_1","article-title":"Acquired Haemophagocytic Lymphohistiocytosis Secondary to Multiple Myeloma","volume":"12","author":"Bhatt R.","year":"2019","journal-title":"BMJ"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58101350"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00273-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/crom\/5582848"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02516-1"},{"issue":"4","key":"e_1_2_10_16_1","article-title":"Cytokine Storms in COVID\u201019, Hemophagocytic Lymphohistiocytosis, and CAR\u2010T Therapy","volume":"8","author":"Long J. P.","year":"2025","journal-title":"JAMA"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:43:28Z","timestamp":1786113808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jha2.70210"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70210","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70210"}}