{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:24:33Z","timestamp":1786123473511,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large B\u2010cell lymphomas (LBCLs) are a common subtype of non\u2010Hodgkin lymphomas. CD19 chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy has revolutionized LBCL treatment, with high remission rates but also significant toxicities, including cytokine release syndrome (CRS) and immune effector cell\u2010associated neurotoxicity syndrome (ICANS). Venous thromboembolism (VTE) in CAR\u2010T therapy patients is understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine the incidence and characteristics of acute VTE in LBCL patients treated with CAR\u2010T therapy and identify baseline clinical features associated with VTE. Methods: We retrospectively reviewed 172 adult LBCL patients treated with CAR\u2010T therapy from January 2018 to November 2019 at MD Anderson Cancer Center. Data on demographics, clinical characteristics, and adverse events were collected. VTE events within 6 months post\u2010CAR\u2010T therapy were confirmed by diagnostic imaging. Statistical analyses included univariate analyses and cumulative incidence functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort was predominantly male (70%), with a median age of 59 years and advanced\u2010stage disease (76.16%). The 6\u2010month incidence of VTE was 7.6%, primarily involving upper extremity events related to central venous catheters. Significant associations were found between VTE and disease histology (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.033) and high\u2010grade ICANS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013). PMBCL patients had a higher VTE incidence (30%) compared to DLBCL and TFL. Most VTE events occurred within the first month post\u2010CAR\u2010T therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LBCL patients receiving CAR\u2010T therapy have a significant risk of VTE, particularly within the first month and among those with PMBCL and high\u2010grade ICANS. This highlights the need to study the role of venous thromboprophylaxis in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70227","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:19:50Z","timestamp":1769782790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Venous Thromboembolism in Aggressive B\u2010Cell Lymphoma Patients Treated with CD19 CAR\u2010T Therapy: Single\u2010Institution Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Neha","family":"Venkatesh","sequence":"first","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-5738","authenticated-orcid":false,"given":"Kevin","family":"Milligan","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Parrish","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-1459","authenticated-orcid":false,"given":"Paolo","family":"Strati","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Ramdial","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Division of Cancer Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sairah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation Division of Cancer Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3929","authenticated-orcid":false,"given":"Cristhiam Rojas","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Section of Benign Hematology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.7774"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.12.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20104363"},{"key":"e_1_2_11_5_1","volume-title":"Chimeric Antigen Receptor T\u2010Cell Therapy","author":"Zhang C.","year":"2024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538\u20107836.2003.00261.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.10.020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S223697"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1852474"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"F. 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