{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:36:45Z","timestamp":1777225005999,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Studies on the efficacy and safety of haploidentical hematopoietic stem cell transplantation (haplo\u2010SCT) with anti\u2010thymocyte globulin (ATG) in patients aged \u2265\u00a060 years remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a study presenting data from 54 patients aged \u2265\u00a060 years with hematologic malignancies who underwent haplo\u2010SCT with ATG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up was 15 months. The median overall survival (OS) at 1\u2010, 2\u2010, and 3\u2010year was 68.4%, 51.2%, and 47.6%, respectively. The cumulative incidence of non\u2010relapse mortality (NRM) at 1 and 3 years post haplo\u2010SCT was 22.9% and 34.8%, respectively. The cumulative incidence of 1\u2010 and 3\u2010years relapse rate was 11.3% and 25.6%. The 100\u2010day cumulative incidence of Grade II\u2013IV acute graft\u2010versus\u2010host disease (aGvHD) was 23.1%, while the 3\u2010year cumulative incidence of extensive chronic graft\u2010versus\u2010host disease (cGvHD) was 10.4%. The absence of complete remission at the time of haplo\u2010SCT was identified as a risk factor for OS, relapse, and NRM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that haplo\u2010SCT with ATG is a safe and effective treatment option for patients aged \u2265\u00a060 years.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : The authors have confirmed clinical trial registration is not needed for this submission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70242","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:39Z","timestamp":1772989299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haploidentical Hematopoietic Stem Cell Transplantation With Anti\u2010Thymocyte Globulin in the Treatment of Older Adults With Hematological Malignancy"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0581-3477","authenticated-orcid":false,"given":"Xin","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-1992","authenticated-orcid":false,"given":"Baoquan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"},{"name":"Department of Hematology The First Affiliated Hospital Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7891","authenticated-orcid":false,"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-616X","authenticated-orcid":false,"given":"Shengli","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-7195","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-3546","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-972X","authenticated-orcid":false,"given":"Suning","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aining","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Jiangsu 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