{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:24:33Z","timestamp":1786123473508,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    T\u2010prolymphocytic leukemia (T\u2010PLL) is a rare lymphoid malignancy with a poor prognosis. B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) also confers a poor prognosis, especially in patients with high\u2010risk features without an option for transplant. Here, we present a case of a patient with T\u2010PLL initially treated with multi\u2010agent chemotherapy who then developed B\u2010ALL, the management strategies, and possible pathogenesis of two concurrent rare malignancies. One proposed mechanism for the development of both hematologic malignancies in this patient is the acquisition of a\n                    <jats:italic>KMT2A<\/jats:italic>\n                    rearrangement, raising the possibility of clonal evolution resulting in therapy\u2010related or secondary leukemia. Another explanation is the presence of a common clonal stem cell progenitor harboring a\n                    <jats:italic>JAK3<\/jats:italic>\n                    mutation.\n                  <\/jats:p>","DOI":"10.1002\/jha2.70252","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T13:49:56Z","timestamp":1771422596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Unique Case of Concomitant T\u2010Prolymphocytic Leukemia and B\u2010Cell Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Viral M.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Hematology\/Oncology University of Texas Southwestern  Dallas Texas USA"},{"name":"Parkland Health and Hospital System  Dallas Texas 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapti","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology\/Oncology University of Texas Southwestern  Dallas Texas USA"},{"name":"Parkland Health and Hospital System  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Chen","sequence":"additional","affiliation":[{"name":"Parkland Health and Hospital System  Dallas Texas USA"},{"name":"Department of Pathology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-2113","authenticated-orcid":false,"given":"Radhika","family":"Kainthla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology\/Oncology University of Texas Southwestern  Dallas Texas USA"},{"name":"Parkland Health and Hospital System  Dallas Texas 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