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This study reports a high\u2010risk T\u2010cell ALL (T\u2010ALL) case with a novel TPR::ABL2 gene fusion resulting from a chromosomal deletion. Overexpression of\n                    <jats:italic>TPR::ABL2<\/jats:italic>\n                    in Ba\/F3 cells promoted cytokine\u2010independent growth, demonstrating its oncogenic nature. Both primary patient and Ba\/F3 cells carrying\n                    <jats:italic>TPR::ABL2<\/jats:italic>\n                    exhibited kinase activation and sensitivity to tyrosine kinase inhibitors (TKIs). This study expands the repertoire of\n                    <jats:italic>ABL2<\/jats:italic>\n                    fusions identified in ALL and supports the incorporation of TKIs into T\u2010ALL treatment regimens to improve outcomes for this subtype.\n                  <\/jats:p>","DOI":"10.1002\/jha2.70255","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:33Z","timestamp":1772989293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of a Novel, Oncogenic and Targetable\n                    <i>TPR::ABL2<\/i>\n                    Fusion Gene in T\u2010Cell Acute Lymphoblastic Leukaemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Elias","family":"Lagonik","sequence":"first","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Sciences, Engineering and Technology The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse. C.","family":"Page","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura N.","family":"Eadie","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"Schutz","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Rehn","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Heatley","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"},{"name":"Australian and New Zealand Children's Haematology\u2010Oncology Group  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Oncology Service Children's Health Queensland Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muirin","family":"Healy","sequence":"additional","affiliation":[{"name":"Paediatrics Department Mackay Base Hospital  Mackay Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag","family":"Whyte","sequence":"additional","affiliation":[{"name":"Haematology Department Queensland Children's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"},{"name":"Haematology Department Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"},{"name":"Haematology Department Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"White","sequence":"additional","affiliation":[{"name":"Precision Cancer Medicine Theme South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide  Adelaide South Australia Australia"},{"name":"Australian and New Zealand Children's Haematology\u2010Oncology Group  Clayton 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N.Eadie D. P.McDougal E.Lagonik et\u00a0al. \u201cThe STAMP Inhibitor Asciminib Is a New Treatment Option for ABL\u2010Rearranged ALL Revealing a Novel Role for the 5' Fusion Partner in Determining Drug Response \u201d priprint bioRxiv 2025."}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:15:41Z","timestamp":1777223741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jha2.70255"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70255","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"2025-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70255"}}