{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:29:59Z","timestamp":1792193399570,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Cutaneous monoclonal gammopathy of clinical significance (MGCS) is rare and may present with scleredema\u2010like fibrosing skin disease.<\/jats:p>\n <\/jats:sec>\n \n Case<\/jats:title>\n A 59\u2010year\u2010old man developed progressive induration of the upper body. Laboratory studies revealed an IgG\/\u03ba monoclonal protein, and skin biopsy showed dermal thickening with mucin deposition. He was refractory to corticosteroids, immunosuppressants, IVIG, plasmapheresis, and bortezomib.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Daratumumab monotherapy led to rapid improvement after 4\u20135 cycles, sustained over 20 cycles, with mobility recovery, mRSS reduction, paraprotein disappearance, and partial histologic regression.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Daratumumab may represent an effective clone\u2010directed therapy for refractory MGCS\u2010associated scleredema.<\/jats:p>\n \n Trial Registration<\/jats:bold>\n : The authors have confirmed clinical trial registration is not needed for this submission\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70262","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:04:46Z","timestamp":1773223486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Scleredema Associated With IgG\/\u03ba Monoclonal Gammopathy of Clinical Significance Successfully Treated With Daratumumab Monotherapy: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Davide","family":"Marcolongo","sequence":"first","affiliation":[{"name":"Hematology Unit Department of Medicine University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bressan","sequence":"additional","affiliation":[{"name":"Institute of Pathology Department of Medicine University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Medicine University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro S. 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