{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:36:52Z","timestamp":1777225012939,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNSF31003A_163232\/1"],"award-info":[{"award-number":["SNSF31003A_163232\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research Foundation","doi-asserted-by":"publisher","award":["KFS\u20104727\u201002\u20102019"],"award-info":[{"award-number":["KFS\u20104727\u201002\u20102019"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Marginal zone lymphoma (MZL) is an indolent yet incurable B\u2010cell malignancy in which targeted agents such as BTK and PI3K inhibitors frequently fail due to resistance or toxicity. Antimicrobial peptides (AMPs), evolutionarily conserved effectors of innate immunity, possess selective cytotoxicity against malignant cells by exploiting tumor\u2010specific membrane alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peptides were synthesized and tested for their anti\u2010proliferative activity in MZL cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We evaluated the antitumor activity of seven natural AMPs, including Antarctic fish\u2013derived trematocines and chionodracine variants, and amphibian temporins, against MZL cell lines (VL51, Karpas1718) and derivatives resistant to BTK, PI3K\u03b4, or PI3K\u03b1\/\u03b4 inhibitors. Among them, W\u2010trematocine and temporin L demonstrated potent dose\u2010dependent cytotoxicity with IC\n                      <jats:sub>50<\/jats:sub>\n                      values of 5.7\u201310\u00a0\u00b5M, maintaining full activity in all resistant models. Other peptides showed moderate activity, while chionodracine\u20101 was inactive. Notably, W\u2010trematocine displayed minimal toxicity toward nonmalignant cells in prior studies, underscoring its selectivity. AMP\u2010mediated killing, driven by membrane disruption and non\u2010apoptotic death pathways, bypassed conventional resistance mechanisms, suggesting therapeutic potential in relapsed\/refractory disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight natural AMPs as promising candidates for development in drug\u2010resistant MZL, warranting further optimization and preclinical validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70267","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:53:43Z","timestamp":1774871623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Peptides Induce Cell Death in Marginal Zone Lymphoma Models Resistant to Targeted Therapies"],"prefix":"10.1002","volume":"7","author":[{"given":"Filippo","family":"Spriano","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Sciences Institute of Oncology Research (IOR) USI  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J.","family":"Arribas","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences Institute of Oncology Research (IOR) USI  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences Institute of Oncology Research (IOR) USI  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Civanelli","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences Institute of Oncology Research (IOR) USI  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Laboratory Affiliated to Pasteur Italia\u2010Fondazione Cenci Bolognetti Department of Biochemical Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Buonocore","sequence":"additional","affiliation":[{"name":"Department for Innovation in Biological Agro\u2010Food and Forest Systems University of Tuscia  Viterbo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences Institute of Oncology Research (IOR) USI  Bellinzona Switzerland"},{"name":"Oncology Institute of Southern Switzerland (IOSI) Ente Ospedaliero Cantonale  Bellinzona 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