{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:36:41Z","timestamp":1777225001836,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    translocation and usually presents with leukocytosis. While somatic mutations can occasionally occur within CML, co\u2010mutations in\n                    <jats:italic>SF3B1<\/jats:italic>\n                    have rarely been reported. We describe a case of concurrent CML and MDS with mutated\n                    <jats:italic>SF3B1<\/jats:italic>\n                    , presenting with macrocytic anemia without leukocytosis. Whole\u2010genome sequencing using Nanopore technology was performed to identify the t(9;22) breakpoint. Probes were designed to target the\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    translocation and the\n                    <jats:italic>SF3B1<\/jats:italic>\n                    mutation. Single\u2010cell DNA sequencing suggested that the\n                    <jats:italic>SF3B1<\/jats:italic>\n                    mutation likely preceded\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    and blunted the expected granulopoiesis, thereby explaining the myelodysplastic syndrome phenotype without leukocytosis. This case illustrates how single\u2010cell analysis can reveal meaningful clonal interactions that would not be evident with traditional bulk sequencing.\n                  <\/jats:p>","DOI":"10.1002\/jha2.70291","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:11:19Z","timestamp":1776262279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent\n                    <i>SF3B1<\/i>\n                    Mutation and\n                    <i>BCR::ABL1<\/i>\n                    Demonstrating a Myelodysplastic Syndrome Phenotype: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Eugene","family":"Brailovski","sequence":"first","affiliation":[{"name":"Jewish General Hospital McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirali","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Lady Davis Research Institute McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Lisi","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine Research Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Dmitrienko","sequence":"additional","affiliation":[{"name":"Jewish General Hospital McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois E.","family":"Mercier","sequence":"additional","affiliation":[{"name":"Jewish General Hospital McGill University  Montreal Quebec Canada"},{"name":"Lady Davis Research Institute McGill University  Montreal Quebec 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