{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:36:41Z","timestamp":1777225001692,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life\u2010threatening disorder characterized by complement\u2010mediated hemolysis. Crovalimab, a novel anti\u2010C5 monoclonal antibody, may offer a more convenient alternative to current therapies, highlighting the need for a comprehensive analysis of its efficacy and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search was conducted through PubMed, Embase, Cochrane, and clinicaltrials.gov using relevant keywords from inception until January 2025. Statistical calculation was conducted using MetaXL 5.3 by employing a random effects model to estimate the pooled event rates with 95% CI. Heterogeneity was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included four studies involving 275 patients with a mean age of 41.87\u00a0\u00b1\u00a013.34 years with rate of hemolysis control of 86% (95% CI: 77%\u201394%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a073%) and transfusion avoidance in 77% of patients (95% CI: 56%\u201393%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a090%), breakthrough hemolysis of 10% (95% CI: 6%\u201313%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0\n                      <jats:sup>=<\/jats:sup>\n                      \u00a00%) and hemoglobin stabilization in 69% patients (95% CI: 43%\u201390%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a098%). The incidence rate of any adverse event was 89% (95% CI: 76%\u201398%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a087%) and serious adverse events 15% (95% CI: 7%\u201325%,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a074%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed high rates of hemolysis control and transfusion avoidance but significant adverse events. Study heterogeneity and publication bias limit generalizability, highlighting the need for larger, more robust trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70294","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:51:01Z","timestamp":1777053061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Crovalimab in Paroxysmal Nocturnal Hemoglobinuria (PNH): A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"7","author":[{"given":"Hammad","family":"Javaid","sequence":"first","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Qadri","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hameer","family":"Ali","sequence":"additional","affiliation":[{"name":"Chandka Medical College  Larkana Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika Franklin","family":"Chilaka","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson University Hospital  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajiha","family":"Syed","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erum","family":"Habib","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahmida","family":"Zahin","sequence":"additional","affiliation":[{"name":"University of Buckingham Medical School  Buckingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaan","family":"Musani","sequence":"additional","affiliation":[{"name":"Yeditepe University Dentistry Faculty  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salauddin Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"United Medical and Dental College  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniah","family":"Rizwan","sequence":"additional","affiliation":[{"name":"Geisinger Wyoming Valley Medical Center  Wilkes\u2010Barre Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Nabeel","family":"Saddique","sequence":"additional","affiliation":[{"name":"King Edward Medical University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Hajj","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201002\u2010522128"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.28"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010020\u201004052\u2010z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010311381"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061648"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12347"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027760"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010026\u201006792\u2010w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003399"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14339"},{"key":"e_1_2_11_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. 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