{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:25:20Z","timestamp":1786123520339,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Translocations involving\n                    <jats:italic>CCND1<\/jats:italic>\n                    are well described in multiple myeloma (MM), most frequently t(11;14), but rearrangements involving the immunoglobulin kappa (\n                    <jats:italic>IGK<\/jats:italic>\n                    ) locus are rare. We present a case of a 71\u2010year\u2010old female with MM harboring t(2;11)(p11.2;q13), resulting in\n                    <jats:italic>IGK::CCND1<\/jats:italic>\n                    , with cyclin D1 and BCL\u20102 overexpression. Her disease was refractory to multiple conventional therapies. On confirmation of this rearrangement by comprehensive genomic profiling, the decision was made to utilize a venetoclax\u2010based regimen. The patient achieved a stringent complete response that has remained durable for over 3 years. This case highlights a novel and targetable genomic subtype of MM and reinforces the importance of molecular diagnostics in guiding precision therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : The authors have confirmed clinical trial registration is not needed for this submission\n                  <\/jats:p>","DOI":"10.1002\/jha2.70300","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:10:37Z","timestamp":1777644637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision Medicine in a Patient With Multiple Myeloma Presenting With t(2;11) and\n                    <i>CCND1<\/i>\n                    Overexpression"],"prefix":"10.1002","volume":"7","author":[{"given":"Ariel","family":"Siegel","sequence":"first","affiliation":[{"name":"Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Ray","sequence":"additional","affiliation":[{"name":"Multiple Myeloma Center of Excellence Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Pathology Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Pathology Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundar","family":"Jagannath","sequence":"additional","affiliation":[{"name":"Multiple Myeloma Center of Excellence Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Parekh","sequence":"additional","affiliation":[{"name":"Multiple Myeloma Center of Excellence Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Houldsworth","sequence":"additional","affiliation":[{"name":"Department of Pathology Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hearn","family":"Jay Cho","sequence":"additional","affiliation":[{"name":"Multiple Myeloma Center of Excellence Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100921\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15245829"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30525\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001853\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009555\u20106"},{"issue":"8","key":"e_1_2_9_7_1","first-page":"2691","article-title":"Concurrent Activation of a Novel Putative Transforming Gene, Myeov, and Cyclin D1 in a Subset of Multiple Myeloma Cell Lines With T","volume":"95","author":"Janssen J. W.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.2.674.bloodjournal882674"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010021\u201001162\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403459"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201012\u2010471888"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.06.006"},{"issue":"12","key":"e_1_2_9_13_1","first-page":"2228","article-title":"Detection of Immunoglobulin Kappa Light\u2010Chain Gene Rearrangement Patterns by Southern Blot Analysis","volume":"8","author":"Beishuizen A.","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01121"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:53:50Z","timestamp":1786114430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jha2.70300"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70300","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2026-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70300"}}