{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:24:33Z","timestamp":1786123473437,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peripheral T\u2010cell lymphomas (PTCLs) are heterogeneous neoplasms with poor prognosis and marked geographic variation. Data from Taiwan remain limited. We conducted a 15\u2010year retrospective cohort study of 249 patients diagnosed with PTCL at two major centers in southern Taiwan between 2010 and 2024 to characterize regional epidemiology, real\u2010world treatment patterns, and survival outcomes. The cohort demonstrated subtype distribution typical of East Asia, with nodal T follicular helper cell lymphoma, angioimmunoblastic type (22%), extranodal NK\/T\u2010cell lymphoma (21%), and PTCL\u2010NOS (15%) predominating. Most patients presented with high\u2010risk features: 71% Stage III\u2013IV disease, 47% bone marrow involvement, and 64% elevated LDH. Median overall survival was 17.6 months, and event\u2010free survival was 6.4 months. Multivariable analysis identified ECOG performance status \u2265\u00a02, elevated LDH, &gt;\u00a01 extranodal site, and age \u2265\u00a060 years as four independent adverse prognostic factors. Frontline hematopoietic stem cell transplantation (HSCT) showed no significant improvement in outcomes; however, salvage chemotherapy followed by HSCT provided prolonged survival after relapse, with median survival after relapse not reached, compared with 6.1 months with salvage chemotherapy alone. These findings underscore PTCL's persistently poor outcomes and the essential role of salvage HSCT in durable survival. Addressing biological complexity and improving therapeutic strategies remain critical for advancing care.<\/jats:p>\n                  <jats:p>Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p>","DOI":"10.1002\/jha2.70302","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:11:12Z","timestamp":1778083872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral T\u2010Cell Lymphomas in Southern Taiwan: Epidemiology, Treatment Patterns, and Long\u2010Term Outcomes"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4999-1161","authenticated-orcid":false,"given":"Bo\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University 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