{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:24:30Z","timestamp":1790965470916,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Skeletal complications are common in sickle cell disease (SCD). We previously showed that the prevalence of low areal bone mineral density (aBMD) increased with age in a pediatric SCD cohort, even after adjusting for short stature. Data on age\u2010related aBMD trends in young adults is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using retrospective data from the Sickle Cell Clinical Research and Intervention Program (SCCRIP), we converted lumbar spine (LS) and total body (TB) aBMD from 713 SCCRIP participants (49.2% females, ages 6\u201324 years) to age\u2010, sex\u2010, ancestry\u2010, and height\u2010adjusted\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores, using data from healthy African American controls enrolled in the Bone Mineral Density in Childhood Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Low TB bone density prevalence rates increased with age: 29.5% in children (6\u2013&lt;\u00a012 years), 36.7% in adolescents (12\u2013&lt;\u00a018 years), and 42.2% in young adults (18\u201324 years). LS aBMD followed a similar age\u2010related trend. Multivariable analysis revealed older age (OR 1.10, 95% CI 1.06\u20131.16), lower hemoglobin (OR 0.833, 95% CI 0.740\u20130.936), and higher eGFR (OR 1.01, 95% CI 1.00\u20131.02) as independent predictors for low TB BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the progressive decline of aBMD in SCD and underscore the need for early screening to mitigate morbidity due to SCD\u2010related skeletal complications.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : The authors have confirmed clinical trial registration is not needed for this submission\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70306","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:44:41Z","timestamp":1779108281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Low Bone Mineral Density Increases With Age in Sickle Cell Disease"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-6264","authenticated-orcid":false,"given":"Jahnavi","family":"Gollamudi","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Sexton","family":"Lamonica","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Internal Medicine University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragha","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"El\u2010Bashir","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyacinth I.","family":"Hyacinth","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyebimpe","family":"Adesina","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2005.05476.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.med.0000436192.25846.0b"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012838"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025015957"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000512"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018026047"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20541"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18954"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20681"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2025.101565"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27228"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489672"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2023.101437"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010009\u20101249\u2010z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20101111"},{"key":"e_1_2_12_17_1","unstructured":"R. J.Kuczmarski C. L.Ogden L. M.Grummer\u2010Strawn et\u00a0al. CDC Growth Charts: United States Advance Data From Vital and Health Statistics no. 314 (National Center for Health Statistics 2000)."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20100385"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2006.06487.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00180461"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.07.001"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25453"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002426"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2023.101452"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:53:19Z","timestamp":1786114399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jha2.70306"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70306","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70306"}}