{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:25:20Z","timestamp":1786123520326,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Andersen\u2013Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27\u2010year\u2010old man with genetically confirmed Type 1 ATS who developed T\u2010cell acute lymphoblastic leukemia. He was treated according to the GRAALL\u20102014 protocol and achieved sustained complete molecular remission without allogeneic transplantation after 3.5 years of follow\u2010up. Management required careful adaptation to mitigate ATS\u2010related risks. Specifically, QT\u2010prolonging and neurotoxic agents were avoided or substituted, glucose infusions were minimized, and acetazolamide was introduced early. Despite exposure to high\u2010dose corticosteroids and anthracyclines, only moderate, self\u2010limited paralytic episodes occurred during intensive phases. During maintenance, ventricular ectopy and QT prolongation prompted chemotherapy dose adjustments and beta\u2010blocker therapy, leading to rapid normalization. This case highlights the feasibility of delivering intensive chemotherapy in ATS with tailored supportive care. Although likely coincidental, this unprecedented association raises questions about potential links between ion channel dysfunction and leukemogenesis.<\/jats:p>","DOI":"10.1002\/jha2.70316","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T08:00:07Z","timestamp":1779868807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010Cell Acute Lymphoblastic Leukemia in a Young Patient With Andersen\u2013Tawil Syndrome Successfully and Safely Treated With Intensive Chemotherapy Including Potential Precipitating Drugs: A Case Report After 3.5 Years of Follow\u2010up"],"prefix":"10.1002","volume":"7","author":[{"given":"Ramy","family":"Rahm\u00e9","sequence":"first","affiliation":[{"name":"Service H\u00e9matologie clinique et Th\u00e9rapie Cellulaire H\u00f4pital Universitaire Avicenne Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"UFR de Sant\u00e9 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