{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:05:58Z","timestamp":1791230758293,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Lambda immunoglobulin light chain (AL) amyloidosis associated with non\u2010IgM lymphoplasmacytic lymphoma (LPL) is rare and often refractory to conventional therapies. Treatment options for relapsed disease remain limited.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Here we describe the case of a patient with a history of LPL\u2010associated AL amyloidosis who had previously been treated with multiple B\u2010cell\u2010 and plasma\u2010cell\u2010directed regimens. At the time of relapse, pathology demonstrated plasmacytic histology, with BCMA\u2010expressing plasma cells by immunohistochemistry and no detectable B\u2010cell infiltrate. The patient subsequently received investigational B\u2010cell maturation antigen (BCMA)\u2010directed chimeric antigen receptor (CAR) T\u2010cell therapy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Following BCMA\u2010directed CAR T\u2010cell therapy, the patient achieved a complete hematologic response.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case highlights the biologic complexity of LPL\u2010associated AL amyloidosis and supports the use of BCMA\u2010targeted therapy, especially when the relapsing or residual disease is comprised by the plasma cell component.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT06097832.\n <\/jats:p>\n 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