{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:23:08Z","timestamp":1786123388332,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Light chain (AL) amyloidosis and transthyretin amyloid cardiomyopathy (ATTR\u2010CM) are the most common types of cardiac amyloidosis. Despite similar manifestations, prognosis and treatments are distinct, emphasizing the importance of accurate and timely diagnosis. This retrospective cohort study assessed real\u2010world diagnostic workups of adult patients suspected of having AL amyloidosis, wild\u2010type ATTR\u2010CM (ATTRwt\u2010CM), or both (AL amyloidosis\u00a0+\u00a0ATTRwt\u2010CM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from a large electronic health record and integrated claims\u2010clinical database (January 2017\u2013June 2023). Workups within 24 months before the first recorded diagnosis were assessed in cohorts with AL amyloidosis (International Classification of Diseases, Tenth Revision code: E85.81 only), ATTRwt\u2010CM (E85.82 only), or AL amyloidosis\u00a0+\u00a0ATTRwt\u2010CM (E85.81 and E85.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1653, 1055, and 59 patients in the AL amyloidosis, ATTRwt\u2010CM, and AL amyloidosis\u00a0+\u00a0ATTRwt\u2010CM cohorts, respectively, 53%, 61%, and 66% received any type of AL amyloidosis or ATTRwt\u2010CM test. Across respective cohorts, 42%, 40%, and 49% received an AL amyloidosis workup, and 17%, 15%, and 17% underwent complete monoclonal protein testing (MPT) for AL amyloidosis assessment. In the ATTRwt\u2010CM and AL amyloidosis\u00a0+\u00a0ATTRwt\u2010CM cohorts, 50% and 46% received an ATTRwt\u2010CM workup, and 9% and 5% underwent complete MPT before or \u2264\u00a07 days after\n                      <jats:sup>99m<\/jats:sup>\n                      technetium\u2010pyrophosphate scintigraphy. Diagnostic workups were commonly done by cardiac specialists (\u2265\u00a034%) and general medicine providers (\u2265\u00a029%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Notable proportions of patients suspected of having AL amyloidosis, ATTRwt\u2010CM, and AL amyloidosis\u00a0+\u00a0ATTRwt\u2010CM did not undergo adequate guideline\u2010recommended diagnostic testing. Due to clinical urgency, improving disease and diagnostic awareness among clinicians is necessary for early, accurate diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70330","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:38:08Z","timestamp":1781530688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Diagnostic Workup of Patients Suspected for Light Chain Amyloidosis and Wild\u2010Type Transthyretin Amyloid Cardiomyopathy: A Retrospective Cohort Study Using US Electronic Health Records"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-8458","authenticated-orcid":false,"given":"Muhamed","family":"Baljevic","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haechung","family":"Chung","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Alvir","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Feron","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Crowley","sequence":"additional","affiliation":[{"name":"Genesis Research  Hoboken New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrin","family":"Benjumea","sequence":"additional","affiliation":[{"name":"Genesis Research  Hoboken New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindi","family":"Pankratova","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13443"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010052016\u2010100200"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508022"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102017.1.1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.08.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25819"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010022\u201002414\u20106"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102016\u2010310704"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000792"},{"issue":"1","key":"e_1_2_13_11_1","first-page":"67","article-title":"Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology","volume":"21","author":"Kumar S. 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