{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:17Z","timestamp":1791604397908,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Relapsed or refractory mantle cell lymphoma (r\/r MCL) remains difficult to treat despite therapeutic advances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included 10 patients with r\/r MCL treated with glofitamab across five sites in Austria and Italy before European approval (January 2023\u2013May 2024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients were heavily pretreated (median 4.5 prior lines; 5\/10 post\u2010CAR\u2010T). After a median of five cycles, responses were observed in 7\/9 evaluable patients, including complete response in 4\/9. Cytokine\u2010release syndrome occurred in 7\/10 (mostly Grade 1\u20132), including grade 3 events in 2\/10, while ICANS occurred in 2\/10 patients, including one Grade 4 event. Three patients received glofitamab as bridging therapy and all proceeded to CAR\u2010T infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Glofitamab showed encouraging activity and manageable toxicity in heavily pretreated MCL, including as bridging therapy to CAR\u2010T\u2010cell treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70343","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:32:24Z","timestamp":1784223144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glofitamab in Heavily Pretreated Mantle Cell Lymphoma Patients: A Multicenter Real\u2010World Case Series"],"prefix":"10.1002","volume":"7","author":[{"given":"Natalia","family":"Rotter","sequence":"first","affiliation":[{"name":"Internal Medicine I: Hematology and Stem Cell Transplantation Hemostaseology and Medical Oncology Ordensklinikum Linz GmbH, Elisabethinen  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Raderer","sequence":"additional","affiliation":[{"name":"Department of Medicine I Division of Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"List","sequence":"additional","affiliation":[{"name":"Third Medical Department for Hematology and Oncology Hanusch Hospital Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Haslbauer","sequence":"additional","affiliation":[{"name":"Internal Medicine I: Medical Oncology, Hematology and Gastroenterology Salzkammergut Klinikum V\u00f6cklabruck  V\u00f6cklabruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Saini","sequence":"additional","affiliation":[{"name":"Internal Medicine I: Hematology and Stem Cell Transplantation Hemostaseology and Medical Oncology Ordensklinikum Linz GmbH, Elisabethinen  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Egle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology Cancer Research Laboratory of the Department of Internal Medicine III Paracelsus Medical University  Salzburg Austria"},{"name":"Austrian Group for Medical Tumor Therapy (AGMT) Study Group  Vienna 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