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We report a case of a 52\u2010year\u2010old man with multiple myeloma who developed severe ICAHT with secondary myelofibrosis (sMF) after administration of idecabtagene\u2010vicleucel, which was comprehensively improved by autologous hematopoietic stem cell boosting. This case focuses on sMF as a rare but cautionary complication of CAR\u2010T therapy, underscoring the importance of bone marrow biopsy to exclude sMF and of stem cell boosting for the treatment of persistent ICAHT.<\/jats:p>","DOI":"10.1002\/jha2.70348","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:27:11Z","timestamp":1783402031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Effector Cell\u2010Associated Hematotoxicity With Secondary Myelofibrosis Following Idecabtagene\u2010Vicleucel for Multiple Myeloma, Comprehensively Treated With Autologous Hematopoietic Stem Cell Boosting"],"prefix":"10.1002","volume":"7","author":[{"given":"Keishi","family":"Ogura","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine Kyoto Prefectural University of Medicine  Kyoto 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