{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:22Z","timestamp":1791604402618,"version":"4.3.4"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      In\u2010frame Exon 4 deletion (p.L184_K274del) is a rare\n                      <jats:italic>ABL1<\/jats:italic>\n                      splicing variant in chronic myeloid leukemia (CML), the clinical significance of which remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed seven chronic\u2010phase CML patients with this variant, identified by Sanger sequencing during routine monitoring of atypically slow molecular responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients achieved hematologic responses; molecular responses, although attained, were often delayed. No patient progressed to advanced phase disease during a median follow\u2010up of 39.0 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Detection of this kinase\u2010inactive variant should not, in itself, be regarded as a definitive resistance mechanism. Larger collaborative studies using quantitative methodologies are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70361","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:08:35Z","timestamp":1785164915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Clinical Response in Patients With Chronic Myeloid Leukemia With an\n                    <i>ABL1<\/i>\n                    In\u2010Frame Exon 4 Deletion: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Yuto","family":"Kaneda","sequence":"first","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"},{"name":"Division of Cellular Medical Sciences Department of Biochemistry and Molecular Biology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Kanemura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senji","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Hematology Gifu Municipal Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fukuno","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Takayama Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Tsukune","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoiku","family":"Takaku","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"},{"name":"Department of Hematology Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Infectious Disease Gifu University Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010025\u201002664\u2010w"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143300"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201012\u2010326405"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201010\u20100595"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13353"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.65"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4163-24"},{"key":"e_1_2_13_10_1","first-page":"1615","article-title":"Chronic Myeloid Leukemia With an In\u2010Frame Exon 4 Deletion in ABL1 With Acute Abdomen Due to an Intrapelvic Bulky Mass as the Initial Symptom","volume":"62","author":"Ide A.","year":"2021","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100776\u20102"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194820"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:43:02Z","timestamp":1791603782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jha2.70361"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70361","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"2026-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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