{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:56:20Z","timestamp":1790826980388,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470166"],"award-info":[{"award-number":["82470166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400188"],"award-info":[{"award-number":["82400188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200149"],"award-info":[{"award-number":["82200149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170158"],"award-info":[{"award-number":["82170158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100175"],"award-info":[{"award-number":["82100175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100170"],"award-info":[{"award-number":["82100170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231195"],"award-info":[{"award-number":["BK20231195"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210087"],"award-info":[{"award-number":["BK20210087"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our study aims to explore the types of diseases that may cause eosinophilia and the changes in the disease spectrum of different degrees of eosinophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients who were admitted to the First Affiliated Hospital of Soochow University from July 1, 2023 to June 30, 2024, and had at least twice eosinophilia (absolute eosinophil count [ACE] &gt; 0.5 \u00d7 109\/L, the interval between the two tests was \u2265 3 days). Eosinophilia was classified as mild (1.5 \u00d7 109\/L \u2265 ACE &gt; 0.5 \u00d7 109\/L), moderate (5 \u00d7 109\/L \u2265 AEC &gt; 1.5 \u00d7 109\/L), or severe (AEC &gt; 5 \u00d7 109\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1821 patients were included, with a median age of 56 years (2\u201396 years), including 1252 males (68.8%) and a median ACE of 1.02 \u00d7 109\/L (0.53\u201341.35). Here, 1679 cases were diagnosed with diseases that may be related to eosinophilia, allergic diseases were the most common (21.7%, 364\/1679). Eight cases of clonal eosinophilia were diagnosed as myeloid\/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions\u00a0(MLN\u2010TK). Around 91 patients were diagnosed as idiopathic eosinophilia after a series of screening. Here, 71.7% (1305\/1821) of the patients showed mild eosinophilia, allergic diseases (21.7%, 283\/1305) were still the main secondary factors, 23.6% (430\/1821) of the patients showed moderate eosinophilia, hematological malignancies became the most common secondary factors (20.5%, 88\/430), and 86 patients had severe eosinophilia,\u00a0nearly half (40\/86) of the patients were secondary to hematological malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eosinophilia has a wide range of age, and is more common in males. Allergic diseases are the most common secondary factors. Different levels of eosinophilia have different causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70369","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:15:37Z","timestamp":1790824537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Review of 1821 Cases of Eosinophilia in a Single\u2010Center Study in Eastern China"],"prefix":"10.1002","volume":"7","author":[{"given":"Yanan","family":"Ma","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou People's Republic of China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou People's Republic of China"},{"name":"Department of Hematology The First people's Hospital of Yancheng Yancheng Clinical College of Xuzhou Medical University  Yancheng People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First people's Hospital of Yancheng Yancheng Clinical College of Xuzhou Medical University  Yancheng People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology The First people's Hospital of Yancheng Yancheng Clinical College of Xuzhou Medical University  Yancheng People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou People's Republic of China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suning","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou People's Republic of China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102141.2003.04195.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020636"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.15.2403"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)68329\u20102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.07.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16020337"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752\u2010200101000\u201000006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.08.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/338026"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.060102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23515"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204468"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223221146938"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.08.013"},{"key":"e_1_2_11_17_1","volume-title":"Williams Hematology, 10e","author":"Shomali W.","year":"2021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27287"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.826.536"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15569"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010023\u201004961\u2010x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.11.1371\u2010a"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12932\/AP\u2010221220\u20101021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2024.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.09.031"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.09.048"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.07.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.011"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010015\u20108506\u20107"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.11.022"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25945"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022417"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13437"},{"issue":"4","key":"e_1_2_11_34_1","article-title":"A Retrospective Cohort Study of Patients With Eosinophilia Referred to a Tertiary Centre","volume":"69","author":"Hougaard M.","year":"2022","journal-title":"Danish Medical Journal"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010022\u201003402\u20108"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.12.008"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201006\u20101824"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25906"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2020\u2010004982"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.70369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:15:41Z","timestamp":1790824541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jha2.70369"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70369","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70369"}}