{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:22Z","timestamp":1791604402681,"version":"4.3.4"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>CPX\u2010351 is associated with reduced non\u2010hematologic toxicity, but its cardiac safety is not well defined. We prospectively assessed ejection fraction (EF) and global longitudinal strain (GLS) in younger adults with AML treated with a single CPX\u2010351\u2010based induction. Median changes were mild and comparable to standard \u201c7\u00a0+\u00a03\u201d. However, 27% developed clinically significant cardiac changes. These findings support prospective cardiac monitoring and the need for comparative studies.<\/jats:p>\n                  <jats:p>Trial Registration: NCT05599360<\/jats:p>","DOI":"10.1002\/jha2.70373","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:53:31Z","timestamp":1785923611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subclinical Cardiac Changes Following CPX\u2010351 Induction in Adults with Favorable\/Intermediate\u2010Risk AML"],"prefix":"10.1002","volume":"7","author":[{"given":"Chezi","family":"Ganzel","sequence":"first","affiliation":[{"name":"The Hematology and Bone Marrow Transplantation Department The Eisenberg Research and Development Authority Shaare Zedek Medical Center The Hebrew University of Jerusalem  Jerusalem 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