{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:22Z","timestamp":1791604402602,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction:<\/jats:title>\n \n Molecular co\u2010mutations modulate outcomes in\n FLT3<\/jats:italic>\n \u2010mutated AML treated with gilteritinib; real\u2010world data stratified by\n DNMT3A<\/jats:italic>\n co\u2010mutation status are lacking.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively analysed 29 adults with R\/R\n FLT3<\/jats:italic>\n \u2010mutated AML treated at two Italian centres. Sixteen patients with complete molecular profiling were stratified into three subgroups by\n DNMT3A<\/jats:italic>\n and\n NPM1<\/jats:italic>\n co\u2010mutation status.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall response rate was 89.7% (26\/29).\n DNMT3A<\/jats:italic>\n \u2010mutated subgroups showed prolonged OS from gilteritinib initiation versus wild\u2010type group (median not reached vs. 8.8 months; 12\u2010month OS 78%\u00a0vs. 17%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These hypothesis\u2010generating data suggest that\n DNMT3A<\/jats:italic>\n co\u2010mutation status is associated with differential gilteritinib outcomes, supporting comprehensive molecular profiling in\n FLT3<\/jats:italic>\n \u2010mutated AML.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70374","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:33:03Z","timestamp":1785922383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNMT3A<\/i>\n Co\u2010Mutation and Real\u2010World Clinical Outcomes With Gilteritinib in FLT3\u2010Mutated Acute Myeloid Leukaemia Across Molecular Subgroups"],"prefix":"10.1002","volume":"7","author":[{"given":"Francesca","family":"Duca","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca Monza Italy"},{"name":"Haematology and Transplantation Unit Fondazione IRCCS San Gerardo dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Manghisi","sequence":"additional","affiliation":[{"name":"Haematology and Transplantation Unit Fondazione IRCCS San Gerardo dei Tintori Monza 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