{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:16:32Z","timestamp":1789463792487,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Somatic mitochondrial\u2013nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EuroClonality\u2010NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for SMNT\u2010associated structural variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five malignancies (0.66%) harboured SMNTs, predominantly involving\n                      <jats:italic>IGH<\/jats:italic>\n                      genes, with one\n                      <jats:italic>PTEN<\/jats:italic>\n                      gene disruption identified. Breakpoint features supported non\u2010homologous end joining\u2010mediated integration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SMNTs are rare but recurrent events in lymphoid malignancies and may represent stable clonal markers for minimal residual disease monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70387","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:13:56Z","timestamp":1789460036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Somatic Mitochondrial\u2013Nuclear DNA Transfer in Lymphoproliferative Disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"James Peter","family":"Stewart","sequence":"first","affiliation":[{"name":"Johnston Centre for Cancer Research Queens University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Darzentas","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alcoceba","sequence":"additional","affiliation":[{"name":"Cancer Research Center\u2013IBMCC (USAL\u2010CSIC) University Hospital of Salamanca (HUS\/IBSAL), CIBERONC  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Sarasquete","sequence":"additional","affiliation":[{"name":"Cancer Research Center\u2013IBMCC (USAL\u2010CSIC) University Hospital of Salamanca (HUS\/IBSAL), CIBERONC  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony V.","family":"Moorman","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Catherwood","sequence":"additional","affiliation":[{"name":"Belfast City Hospital  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binaya","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pott","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton W.","family":"Langerak","sequence":"additional","affiliation":[{"name":"Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Johnston Centre for Cancer Research Queens University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and Standardization of PCR Primers and Protocols for Detection of Clonal Immunoglobulin and T\u2010Cell Receptor Gene Recombinations in Suspect Lymphoproliferations: Report of the BIOMED\u20102 Concerted Action BMH4\u2010CT98\u20103936","volume":"17","author":"Dongen J. 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