{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:54:18Z","timestamp":1792173258015,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>RUNX1<\/jats:italic>\n                      rearrangements are recurrent in myeloid neoplasms, but rare fusion partners remain poorly characterized. We report the first acute myeloid leukemia (AML) with a\n                      <jats:italic>RUNX1::ZFPM2<\/jats:italic>\n                      fusion generated by t(8;21)(q23;q22). A 72\u2010year\u2010old woman presented with acute myelomonocytic leukemia carrying concomitant\n                      <jats:italic>IDH2<\/jats:italic>\n                      and\n                      <jats:italic>NRAS<\/jats:italic>\n                      mutations. Azacitidine\u2013venetoclax induced transient remission with a marked decrease in the fusion transcript. However, persistent cytopenias, molecular relapse, and treatment resistance led to death 1 year after diagnosis. This case expands the spectrum of\n                      <jats:italic>RUNX1<\/jats:italic>\n                      \u2010rearranged AML and suggests a biological behavior distinct from classical\n                      <jats:italic>RUNX1::RUNX1T1<\/jats:italic>\n                      \u2010positive AML.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70395","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:31:43Z","timestamp":1792171903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematologic Malignancies With\n                    <i>RUNX1::ZFPM2<\/i>\n                    Translocation: A Case Report and Literature Review"],"prefix":"10.1002","volume":"7","author":[{"given":"Marie","family":"Temple","sequence":"first","affiliation":[{"name":"Biological Hematology Department Cochin Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Biological Hematology Department Cochin Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Balducci","sequence":"additional","affiliation":[{"name":"Biological Hematology Department Necker Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Couronn\u00e9","sequence":"additional","affiliation":[{"name":"Biological Hematology Department Necker Hospital AP\u2010HP  Paris 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