{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:28:18Z","timestamp":1793582898796,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monomorphic epitheliotropic intestinal T\u2010cell lymphoma (MEITL) is a rare, aggressive malignancy with a median overall survival (OS) of 7\u201315 months. The Newcastle regimen, comprising cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), ifosfamide, etoposide, and epirubicin (IVE), and intermediate\u2010dose methotrexate for central nervous system (CNS) prophylaxis, has demonstrated promising outcomes in enteropathy\u2010associated T\u2010cell lymphoma (EATL) but has not been evaluated in MEITL, where the CNS relapse risk informing methotrexate use remains poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this real\u2010world cohort of 56 patients with MEITL diagnosed from 2002 to 2025, outcomes were compared between those who received the modified Newcastle (mNewcastle) regimen omitting methotrexate (CHOP\/IVE) and those treated with CHOP\u2010based chemotherapy. Survival was estimated using the Kaplan\u2013Meier method with multivariable Cox regression, and CNS relapse was analyzed using a competing risks framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 52 patients receiving systemic chemotherapy, 22 received the mNewcastle regimen and 28 received CHOP\u2010based chemotherapy, with comparable baseline characteristics. With a median follow\u2010up of 50 months, the mNewcastle was associated with significantly longer median progression\u2010free survival (PFS; 14.4 vs. 6.6 months,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021) and OS (28.7 vs. 11.7 months,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021). In multivariable analysis, mNewcastle remained an independent predictor of improved PFS (hazard ratio [HR], 0.44;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020) and showed a trend toward improved OS (HR, 0.51;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.077). The 2\u2010year cumulative incidence of CNS relapse was 12.1% (95% CI, 2.9\u201321.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The mNewcastle regimen may provide superior survival compared with CHOP\u2010based chemotherapy in MEITL, while CNS relapse remains a clinical concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : The authors have confirmed clinical trial registration is not needed for this submission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70400","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:25:47Z","timestamp":1790195147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modified Newcastle Regimen Improves Survival Despite Central Nervous System Relapse in Monomorphic Epitheliotropic Intestinal T\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Minseung","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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