{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:00:16Z","timestamp":1790622016260,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Biological overlap between Felty syndrome (FS) and clonal cytotoxic T\u2010cell disorders is increasingly recognized, but aggressive progression is uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated an autopsy\u2010confirmed case of terminal aggressive clonal T\u2010cell disease that developed after a 4\u2010year clinical course diagnosed as FS using serial immunophenotypic and molecular analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Evolving \u03b3\u03b4 T\u2010cell populations, TCR clonality, shared\n                      <jats:italic>STAT3<\/jats:italic>\n                      and\n                      <jats:italic>TET2<\/jats:italic>\n                      mutations, and a newly emergent complex karyotype supported clonal continuity and terminal aggressive progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case provides clinicopathological evidence of long\u2010term evolution in FS\u2010associated clonal cytotoxic T\u2010cell disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70406","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:01Z","timestamp":1790618161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Felty Syndrome\u2013Associated Clonal Cytotoxic T\u2010Cell Disease With Terminal Aggressive Progression: Shared\n                    <i>STAT3<\/i>\n                    and\n                    <i>TET2<\/i>\n                    Mutations Across a Prolonged Disease Course"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-031X","authenticated-orcid":false,"given":"Kei","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"},{"name":"Department of Hematology Gunma Prefectural Cancer Center  Ohta Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yokohama","sequence":"additional","affiliation":[{"name":"Division of Transfusion Service Gunma University Hospital Faculty of Medicine Gunma University  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh","family":"Kwan Ee","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoka","family":"Sorimachi","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences Gunma University Graduate School of Health Sciences  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shirakura","sequence":"additional","affiliation":[{"name":"Clinical Department of Pathology Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumihito","family":"Nobusawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School Medicine  Meabashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201008\u2010692590"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"227","article-title":"The Non\u2010Leukemic T Cell Large Granular Lymphocytic Leukemia Variant With Marked Splenomegaly and Neutropenia in the Setting of Rheumatoid Arthritis\u2014Felty Syndrome and Hepatosplenic T Cell Lymphoma Mask","volume":"11","author":"Gorodetskiy V.","year":"2021","journal-title":"American Journal of Blood 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