{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:41Z","timestamp":1790618261527,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multiple myeloma is the second most common malignancy of the lymphoid system and accounts for about 2% of cancer deaths. Treatment generally consists of chemotherapy and autologous stem cell transplantation. Clinical trial results are equivocal as to whether autologous stem cell transplantation in the treatment of multiple myeloma prolongs overall survival. One possible etiology for this conundrum could be that the transplanted autologous stem cells may also contain residual tumor cells\/tumor stem cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Residual autologous stem cells from patients undergoing stem cell transplantation were examined for cells containing monoclonal immunoglobulins and clonotypic DNA detected in diagnostic bone marrow to determine if malignant myeloma cells may have been transplanted along with hematopoietic stem cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all eight cases of autologous stem cell transplants examined from multiple myeloma patients, the infused cells included cells containing monoclonal immunoglobulins of the same type as were noted in patients' sera at the time of diagnosis. This was not seen in allogeneic cells from donors without cancer. In all four cases in which a dominant clone was identified by molecular analysis in the diagnostic bone marrow, the same clone was detectable in the autologous stem cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We posit that lack of prolongation of overall survival with autologous stem cell transplantation in multiple myeloma is in part due to infusion of cells containing tumor cells that repopulate the recipient. This finding may warrant novel collection and processing strategies to mitigate the infusion of malignant cells. Until such methods become available, the use of autologous stem cell transplantation should be considered in the context of the conundrum reported here.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70408","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:10:32Z","timestamp":1790615432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Characterization of Mobilized Apheresis Hematopoietic Progenitor Cells Designated for Autologous Stem Cell Transplantation in Multiple Myeloma"],"prefix":"10.1002","volume":"7","author":[{"given":"Gurmukh","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pathology Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiana","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni J.","family":"Bollag","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020\u20100141"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4177"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3049w"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101929"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000645\u20101"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)00389\u20107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/S1470-2045(21)00535-0","article-title":"Carfilzomib With Cyclophosphamide and Dexamethasone or Lenalidomide and Dexamethasone Plus Autologous Transplantation or Carfilzomib Plus Lenalidomide and Dexamethasone, Followed by Maintenance With Carfilzomib Plus Lenalidomide or Lenalidomide Alone for Patients With Newly Diagnosed Multiple Myeloma (FORTE): A Randomised, Open\u2010Label, Phase 2 Trial","volume":"22","author":"Gay F.","year":"2021","journal-title":"Lancet Oncology"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106710\u201016"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.5032"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611750"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204925"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705935"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plabm.2021.e00256","article-title":"Multiple Myeloma: Detection of Free Monoclonal Light Chains by Modified Immunofixation Electrophoresis With Antisera Against Free Light Chains","volume":"27","author":"Wilhite D.","year":"2021","journal-title":"Practical Laboratory Medicine"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17152439"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.10.018"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010023\u201005427\u20108"},{"key":"e_1_2_13_18_1","first-page":"13","article-title":"The Ex Vivo Purge of Cancer Cells Using Oncolytic Viruses: Recent Advances and Clinical Implications","volume":"4","author":"Tsang J. 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