{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:52Z","timestamp":1790618272648,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Automated erythrocytapheresis (aEEX) is an effective therapy for severe sickle cell disease (SCD). Its use in paediatrics can be limited by challenges in obtaining reliable venous access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, single\u2010centre study to evaluate the safety and feasibility of ultrasound (US)\u2010guided peripheral venous catheter (PVC) placement for aEEX compared with central venous catheter (CVC) use in children and adolescents with SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between May 2018 and July 2025, 99 aEEX procedures using PVC were compared with 44 using CVC in 23 patients (median age: 16.4 years). The most frequent indication was severe disease phenotype (62.9%), defined as recurrent vaso\u2010occlusive crises and\/or splenic sequestration and\/or acute chest syndrome despite optimal hydroxyurea therapy. The procedure success rate was 99.0% for PVC and 97.7% for CVC, with median post\u2010apheresis HbS of 26.5% and 24.0%, respectively. Complications, mostly transient and without clinical impact, occurred in 9.1% of PVC procedures and 6.8% of CVC procedures. No infectious or and thrombotic events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that aEEX under light sedation with US\u2010guided PVC placement is a safe, well\u2010tolerated and effective alternative to CVC in selected paediatric patients with SCD. This approach may expand access to aEEX reducing reliance on CVC and manual exchange procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70409","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:13:01Z","timestamp":1790615581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Peripheral Venous Catheter for Automated Erythrocytapheresis in a Paediatric Population Affected by Sickle Cell Disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Laura","family":"Ocello","sequence":"first","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pavan","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia M.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Guerra","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Moretto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tassistro","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Epidemiology Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Bicocca Center of Bioinformatics Biostatistics and Bioimaging (B4 centre) School of Medicine and Surgery University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lepri","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Gregorio","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Passoni","sequence":"additional","affiliation":[{"name":"Psychology e Psychotherapy Paediatric Department Fondazione MBBM, Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Balduzzi","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"},{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Baldini","sequence":"additional","affiliation":[{"name":"Immunohaematology and Transfusion Service Apheresis Unit Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Corti","sequence":"additional","affiliation":[{"name":"ERN\u2010EuroBloodNet Member Paediatric Department Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1016\/S2352-3026(23)00118-7","article-title":"Global, Regional, and National Prevalence and Mortality Burden of Sickle Cell Disease, 2000\u20132021: A Systematic Analysis From the Global Burden of Disease Study 2021","volume":"10","author":"Thomson A. M.","year":"2023","journal-title":"Lancet Haematology"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/ejh.13212","article-title":"Insight Into the Complex Pathophysiology of Sickle Cell Anaemia and Possible Treatment","volume":"102","author":"Piccin A.","year":"2019","journal-title":"European Journal of Haematology"},{"key":"e_1_2_9_4_1","volume-title":"Linee guida per la gestione della malattia drepanocitica in et\u00e0 pediatrica in Italia","author":"Casale M.","year":"2018"},{"issue":"8","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1182\/bloodadvances.2019001142","article-title":"American Society of Hematology 2020 Guidelines for Sickle Cell Disease: Prevention, Diagnosis, and Treatment of Cerebrovascular Disease in Children and Adults","volume":"4","author":"DeBaun M. 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