{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:51:24Z","timestamp":1791521484865,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary central nervous system lymphoma (PCNSL) remains a distinct and aggressive malignancy whose underlying antigenic triggers are largely unknown. While autoantigens such as neurabin\u2010I and SAMD14 have been implicated, the potential role of infectious agents in driving clonal B\u2010cell receptor selection within the central nervous system remains less understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A viral proteome microarray screening approach encompassing 158 viral entities was utilized to test tumor\u2010derived recombinant B\u2010cell receptors from PCNSL. Furthermore, we analyzed a validation cohort comprising 22 PCNSL patients and tested expanded control sera from 188 healthy individuals. Functional assays were performed to confirm B\u2010cell receptor activation and downstream signaling upon cognate antigen engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Screening identified a distinct B\u2010cell receptor reactivity directed against Coxsackievirus A24 in a PCNSL case, which was completely absent across non\u2010PCNSL lymphomas. Validation testing in an independent cohort confirmed rare reactivity (1\/22, 4.55%). Control serum analysis revealed weak reactivity in 1 out of 188 healthy individuals (0.53%). Functional assays demonstrated that the Coxsackievirus A24\u2010derived antigen is capable of triggering antigen\u2010specific receptor signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report the first evidence linking PCNSL B\u2010cell receptor reactivity to a viral antigen, identifying Coxsackievirus A24 as a rare ligand. While functional assays confirm the capacity for receptor activation, the findings must be interpreted cautiously as hypothesis\u2010generating. Further investigation in larger independent cohorts is required to determine whether viral antigens play any meaningful pathogenic role in this malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70422","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:47:33Z","timestamp":1791521253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare But Specific B\u2010Cell Receptor Reactivity Against Coxsackievirus A24 in Primary Central Nervous System Lymphomas"],"prefix":"10.1002","volume":"7","author":[{"given":"Igor Age","family":"Kos","sequence":"first","affiliation":[{"name":"Jos\u00e9 Carreras Center for Immuno\u2010 and Gene Therapy of Department of Internal Medicine I, Hematology, Oncology, Rheumatology and Clinical Immunology Saarland University Medical School  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Cetin","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Carreras Center for Immuno\u2010 and Gene Therapy of Department of Internal Medicine I, Hematology, Oncology, Rheumatology and Clinical Immunology Saarland University Medical School  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Fadle","sequence":"additional","affiliation":[{"name":"Jos\u00e9 Carreras Center for Immuno\u2010 and Gene Therapy of Department of Internal Medicine I, Hematology, Oncology, Rheumatology and Clinical Immunology Saarland University Medical School  Homburg 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Smola","sequence":"additional","affiliation":[{"name":"Institute of Virology Saarland University Medical Center  Homburg Germany"},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Centre for Infection Research  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology University 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