{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:53:51Z","timestamp":1791258831731,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pregnancy after unsuccessful treatment\u2010free remission (TFR) in chronic\u2010phase chronic myeloid leukemia (CP\u2010CML) remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A woman lost major molecular response (MMR) after stopping a\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      tyrosine kinase inhibitor (TKI). Ponatinib re\u2010consolidation enabled a second TKI\u2010free interval, with MMR maintained but deep molecular response unstable. With diminished ovarian reserve, embryos were cryopreserved using assisted reproductive technology (ART), separating fertility preservation from pregnancy timing. Further ponatinib re\u2010consolidation restored MR4.5; ponatinib was stopped before embryo transfer, resulting in pregnancy and live birth without TKI exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sequential ponatinib re\u2010consolidation and ART may enable planned TKI interruption for pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70426","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:41:27Z","timestamp":1791258087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Pregnancy After Planned Pregnancy\u2010Oriented TKI Interruption and Embryo Transfer Following Ponatinib Re\u2010Consolidation in Chronic\u2010Phase Chronic Myeloid Leukemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Fumisato","family":"Takagi","sequence":"first","affiliation":[{"name":"Division of Hematology Internal Medicine III Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu 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