{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:39:29Z","timestamp":1792348769820,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n \n \n Deletions at 13q14 or unbalanced translocations involving this region are the most common chromosomal abnormalities observed in B\u2010cell chronic lymphocytic leukemia (CLL). This locus is known to harbor the tumor suppressor microRNAs,\n miR\u201015a\/16\u20101<\/jats:italic>\n , loss of which leads to increased expression of the anti\u2010apoptotic protein Bcl2 at the post\u2010transcriptional level, ultimately promoting leukemic cell survival. In this report, we describe a novel\n DLEU2<\/jats:italic>\n ::BCL2<\/jats:italic>\n fusion identified by next\u2010generation sequencing in an individual in their 70s with CLL. The fusion preserved the\n BCL2<\/jats:italic>\n coding sequence while disrupting the\n DLEU2\/miR\u201015a\/16\u20101<\/jats:italic>\n region. RNA expression analysis demonstrated a marked increase in\n BCL2<\/jats:italic>\n transcripts. Fluorescence in situ hybridization revealed that this rearrangement was associated with both monoallelic and biallelic deletions at 13q14. These findings suggest that insertion of\n BCL2<\/jats:italic>\n into the 13q14 locus may both truncate\n DLEU2<\/jats:italic>\n , thereby impairing the tumor\u2010suppressive function of\n miR\u201015a\/16\u20101<\/jats:italic>\n , and place\n BCL2<\/jats:italic>\n under the control of the\n DLEU2<\/jats:italic>\n promoter, contributing to increased transcriptional activity. This case highlights a potential dual mechanism of Bcl2 dysregulation in CLL and underscores the pathogenic significance of rare 13q14 translocations, further expanding the understanding of genomic complexity in this disease.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70434","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:40:56Z","timestamp":1792345256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel\n BCL2<\/i>\n Translocation and Concurrent Chromosome 13q14 Deletion in Chronic Lymphocytic Leukemia: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Riku","family":"Das","sequence":"first","affiliation":[{"name":"Molecular Pathology and Cytogenomics Division of Laboratory Medicine Robert J. Tomsich Department of Pathology & Laboratory Medicine Diagnostics Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Bosler","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Cytogenomics Division of Laboratory Medicine Robert J. Tomsich Department of Pathology & Laboratory Medicine Diagnostics Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Astbury","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Cytogenomics Division of Laboratory Medicine Robert J. Tomsich Department of Pathology & Laboratory Medicine Diagnostics Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.159"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201643"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.11.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.12.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.11.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102264(199709)20:1<73::AID\u2010GCC11>3.0.CO;2\u2010G"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"456","article-title":"Bcl\u20102 Expression in Chronic Lymphocytic Leukemia and Its Correlation With the Induction of Apoptosis and Clinical Outcome","volume":"10","author":"Robertson L. 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