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Inhibition of this process has demonstrated substantial antimyeloma activity in preclinical studies, both alone and in combination with established MM therapeutics. Based on a clinical trial programme encompassing multiple combination regimens, selinexor\u2010based therapy has been approved for the treatment of relapsed\/refractory MM (RRMM), with selinexor\u2010dexamethasone approved in the later\u2010relapse setting for penta\u2010refractory patients and selinexor\u2010bortezomib\u2010dexamethasone approved for patients who have received \u22651 prior therapy. Here, we provide a comprehensive review of the clinical data on selinexor\u2010based regimens, including recent updates from the 2022 American Society of Hematology annual meeting, and summarise ongoing studies of this novel targeted agent in newly diagnosed MM and RRMM.<\/jats:p>","DOI":"10.1002\/jha2.709","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:40:54Z","timestamp":1684219254000},"page":"792-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Selinexor: Targeting a novel pathway in multiple myeloma"],"prefix":"10.1002","volume":"4","author":[{"given":"Clifton C.","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Jerome Lipper Center for Multiple Myeloma Research Harvard Medical School  Boston Massachusetts 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