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We investigated whether the amount of cfDNA of human T\u2010cell leukemia virus type 1 (HTLV\u20101) correlates with disease state in adult T\u2010cell leukemia\u2010lymphoma (ATL). HTLV\u20101 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV\u20101 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV\u20101 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.<\/jats:p>","DOI":"10.1002\/jha2.725","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T06:40:11Z","timestamp":1685169611000},"page":"733-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["HTLV\u20101 cell\u2010free DNA in plasma as a potential biomarker in HTLV\u20101 carriers and adult T\u2010cell leukemia\u2010lymphoma"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-4357","authenticated-orcid":false,"given":"Hiroo","family":"Katsuya","sequence":"first","affiliation":[{"name":"Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University  Saga 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