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The overall response rate obtained with B\u2010cell maturation antigen (BCMA)\u2010targeting BsAbs is approximately 60%\u201370%, including a high proportion of patients achieving very good partial response or complete response. Comparable efficacy is seen with BsAbs targeting GPRC5D or FcRH5. Cytokine release syndrome is frequently observed with BsAb treatment, but mostly during the step\u2010up doses and the first full dose. Early intervention with IL\u20106 receptor blocking antibodies (e.g., tocilizumab) prevents escalation to severe manifestations. Infections are also common during treatment and related to the extent of exposure to immune suppressive anti\u2010MM agents, as well as development of hypogammaglobulinemia due to elimination of normal plasma cells, and probably because of T\u2010cell exhaustion resulting from continuous BsAb\u2010mediated T\u2010cell activation. Adequate monitoring for infections and institution of infectious prophylaxis are essential. Patients treated with GPRC5D\u2010targteing BsAbs often develop skin and nail disorders and loss of taste, which is likely related to GPRC5D expression in cells that produce hard keratin. Currently ongoing studies are aiming at further improving these results by evaluating BsAbs in combination with other drugs, such as immunomodulatory agents and anti\u2010CD38 antibodies, as well as the application of BsAbs in earlier lines of therapy, including patients with newly diagnosed disease. We expect that the outcomes of patients with MM will further improve by the introduction of this novel type of T\u2010cell immunotherapy.<\/jats:p>","DOI":"10.1002\/jha2.729","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:12:01Z","timestamp":1686193921000},"page":"811-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["T\u2010cell redirecting bispecific antibodies in multiple myeloma: Current landscape and future directions"],"prefix":"10.1002","volume":"4","author":[{"given":"Chloe","family":"O'Neill","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam Department of Hematology  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Cancer Biology and Immunology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-2603","authenticated-orcid":false,"given":"Niels W. 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