{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:48:40Z","timestamp":1768031320960,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["KAW 2015.0030"],"award-info":[{"award-number":["KAW 2015.0030"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["KAW 2015.0275"],"award-info":[{"award-number":["KAW 2015.0275"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015\u201002375"],"award-info":[{"award-number":["2015\u201002375"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["190119 Pj01H"],"award-info":[{"award-number":["190119 Pj01H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["190109 SCIA"],"award-info":[{"award-number":["190109 SCIA"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The abundant hepatocyte\u2010expressed plasma protein histidine\u2010rich glycoprotein (HRG) enhances antitumor immunity by polarizing inflammatory and immune cells in several mouse models, however, the clinical relevance of HRG in human cancer is poorly explored. The expression and role of HRG in human B\u2010cell lymphomas was investigated in order to find new tools for prognosis and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Immunohistochemical (IHC) analysis and RNA hybridization of tissue microarrays showed that (i) HRG was expressed by tumor cells in marginal zone lymphoma (MZL), in 36% of 59 cases. Expression was also detected in follicular lymphoma (22%), mantle cell lymphoma (19%), and indiffuse large B\u2010cell lymphoma (DLBCL;5%) while primary CNS lymphoma (PCNSL) lacked expression of HRG. (ii) MZL patients positive for HRG showed a superior overall survival outcome (HR\u00a0=\u00a00.086, 95% CI\u00a0=\u00a00.014\u20100.518, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.007), indicating a protective role for HRG independent of stage, age and sex. (iii) HRG\u2010expressing MZL displayed significantly increased transcript and protein levels of the host defense peptide alpha defensin 1. In addition, global transcript analyses showed significant changes in gene ontology terms relating to immunity and inflammation, however, infiltration of immune and inflammatory cells detected by IHC was unaffected by HRG expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HRG expression by MZL tumor cells correlates with an altered transcription profile and improved overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.73","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T21:11:53Z","timestamp":1596748313000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Marginal zone lymphoma expression of histidine\u2010rich glycoprotein correlates with improved survival"],"prefix":"10.1002","volume":"1","author":[{"given":"Tor","family":"Persson Skare","sequence":"first","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross O","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis P","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Lindskog","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Sander","sequence":"additional","affiliation":[{"name":"Dept of Laboratory Medicine Division of Pathology Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-1106","authenticated-orcid":false,"given":"Alex R","family":"Gholiha","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-5252","authenticated-orcid":false,"given":"Rose\u2010Marie","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-2000","authenticated-orcid":false,"given":"Lena","family":"Claesson\u2010Welsh","sequence":"additional","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life and Beijer Laboratories and Unit of Experimental and Clinical Oncology Uppsala University  Uppsala 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