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Flow cytometry immunophenotyping plays an important role in recognizing the unique immunophenotype of bright CD56 expression with dim\/negative expression of HLA\u2010DR, CD38, and CD45 termed the RAM immunophenotype in this entity. Still, CBFA2T3::GLIS2\u2010positive acute leukemia with T\/megakaryocytic markers could be misdiagnosed as T\u2010lymphoblastic leukemia\/lymphoma, early T\u2010cell precursor acute lymphoblastic\u00a0leukemia\/lymphoma, NK lymphoblastic leukemia, AML with minimal differentiation, or AML with myelodysplasia\u2010related changes.<\/jats:p>","DOI":"10.1002\/jha2.741","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T17:04:56Z","timestamp":1687799096000},"page":"765-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>CBFA2T3::GLIS2<\/i>\u2010positive acute leukemia with RAM and mixed T\/megakaryocytic phenotype"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-6943","authenticated-orcid":false,"given":"Mahsa","family":"Khanlari","sequence":"first","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Y","family":"Bolen","sequence":"additional","affiliation":[{"name":"Department of Oncology Novant Health Presbyterian Medical Center Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Sebastian Bautista","family":"Otanez","sequence":"additional","affiliation":[{"name":"Department of Oncology Novant Health Presbyterian Medical Center Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa V.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee 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