{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:11:16Z","timestamp":1781539876172,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deeper responses are associated with longer survival in multiple myeloma (MM); however, limited data exist on the impact of response kinetics on outcomes. We investigated progression\u2010free survival (PFS) and duration of response (DOR) by response depth and in early (best confirmed response 0\u20134 months; <jats:italic>n<\/jats:italic>\u00a0=\u00a0424) versus late responders (best confirmed response\u00a0&gt;4 months; <jats:italic>n<\/jats:italic>\u00a0=\u00a0281). Newly diagnosed patients enrolled in TOURMALINE\u2010MM2 receiving ixazomib\u2010lenalidomide\u2010dexamethasone (IRd) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0351) or placebo\u2010Rd (<jats:italic>n<\/jats:italic>\u00a0=\u00a0354) were evaluated <jats:italic>post hoc<\/jats:italic>. Deeper responses were associated with longer PFS (complete response [CR] not reached [NR], very good partial response [VGPR] 37.2 months, partial response [PR] 16.4 months) and DOR (CR NR, VGPR 42.6 months, PR 15.4 months). Among patients with a PFS (<jats:italic>n<\/jats:italic>\u00a0=\u00a0511) or DOR (<jats:italic>n<\/jats:italic>\u00a0=\u00a0484) of \u22656 months who achieved \u2265PR, median PFS was prolonged among late versus early responders receiving IRd (59.7\u00a0vs. 17.9 months) or placebo\u2010Rd (56.6\u00a0vs. 12.4 months), as was median DOR (IRd, NR vs. 20.9 months; placebo\u2010Rd, 58.2\u00a0vs. 11.7 months). While the treatment paradigm for newly diagnosed MM is treatment to progression, our findings suggest slowness of response to a proteasome inhibitor\u2010immunomodulatory drug\u2010steroid combination is not a negative predictor of outcome.<\/jats:p>","DOI":"10.1002\/jha2.759","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:40:22Z","timestamp":1691055622000},"page":"995-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Late versus early response and depth of response are associated with improved outcomes in patients with newly diagnosed multiple myeloma enrolled in the TOURMALINE\u2010MM2 trial"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-8865","authenticated-orcid":false,"given":"Paul G.","family":"Richardson","sequence":"first","affiliation":[{"name":"Harvard Medical School Jerome Lipper Multiple Myeloma Center, Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Facon","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Lille Service des Maladies du Sang, University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Venner","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute University of Alberta  Edmonton Alberta Canada"},{"name":"BC Cancer Vancouver Centre University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-7034","authenticated-orcid":false,"given":"Nizar J.","family":"Bahlis","sequence":"additional","affiliation":[{"name":"Arnie Charbonneau Cancer Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Offner","sequence":"additional","affiliation":[{"name":"UZ Gent  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell","family":"White","sequence":"additional","affiliation":[{"name":"QEII Health Sciences Center and Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Karlin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lyon Sud, Pierre\u2010Benite  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotfi","family":"Benboubker","sequence":"additional","affiliation":[{"name":"CHRU TOURS  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Voog","sequence":"additional","affiliation":[{"name":"Clinique Victor Hugo  Le Mans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Soo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-5337","authenticated-orcid":false,"given":"Kenshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Japan Red Cross Medical Center  Shibuya\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. 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