{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:30:37Z","timestamp":1784662237371,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R249\u2010A14646\u201019\u2010S70"],"award-info":[{"award-number":["R249\u2010A14646\u201019\u2010S70"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pomalidomide\u2010dexamethasone (Pd) has been a standard care treatment for relapsed and refractory multiple myeloma since 2013. However, the outcomes of Pd after exposure to CD38 antibodies are not known. Here we describe the real\u2010world use and efficacy of pomalidomide in a Danish, nationwide cohort of daratumumab\u2010exposed patients. We identified 328 patients that were treated with pomalidomide. Of these, 137 received Pd, 65 daratumumab\u2010pomalidomide\u2010dexamethasone (DPd), 43 pomalidomide\u2010cyclophosphamide\u2010dexamethasone (PCd), 19 carfilzomib\u2010pomalidomide\u2010dexamethasone (KPD), 11 pomalidomide\u2010bortezomib\u2010dexamethasone (PVd), and 52 pomalidomide in other combinations. Patients treated with Pd in this cohort had a partial response or better (\u2265\u00a0PR) rate of 35.8% and median time to next treatment (mTNT) of 4.9 months, almost identical to the results of previous prospective clinical trials. Although treatment with the various pomalidomide\u2010containing triplet regimens resulted in higher\u00a0\u2265\u00a0PR rates (PCd: 46.5%, PVd: 63.6%, DPd: 55.4%, KPd: 63.2%), the mTNT achieved was not significantly better than with Pd in most cases (PCD: 5.4, PVD: 5.3, DPD: 4.7 months). The exception to this was KPd (mTNT 7.4 months), but this regimen was mainly used earlier in the course of the disease (median time from diagnosis 2.3 years vs. 3.7\u20134.3 years). The most important predictor of outcomes was not the choice of index regimen (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.72), but prior exposure (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0116). Compared to CD38 antibody\u2010na\u00efve patients, triple\u2010class\u2010exposed patients achieved reduced\u00a0\u2265\u00a0PR rate (38.0%\u00a0vs. 47.3%), shorter mTNT (4.0\u00a0vs. 5.9 months), and shorter median overall survival (12.4\u00a0vs. 24.2 months) with pomalidomide treatment.<\/jats:p>","DOI":"10.1002\/jha2.774","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:39:43Z","timestamp":1692941983000},"page":"1006-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The real\u2010world use and efficacy of pomalidomide for relapsed and refractory multiple myeloma in the era of CD38 antibodies"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-7007","authenticated-orcid":false,"given":"Agoston Gyula","family":"Szabo","sequence":"first","affiliation":[{"name":"Department of Hematology Vejle Hospital  Vejle Denmark"},{"name":"Department of Hematology, Rigshospitalet Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Thorsen","sequence":"additional","affiliation":[{"name":"COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Fladeland","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Hematology Vejle Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette B\u00f8egh","family":"Levring","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-5336","authenticated-orcid":false,"given":"Emil","family":"Hermansen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet Copenhagen University  Copenhagen Denmark"},{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-4869","authenticated-orcid":false,"given":"S\u00f8ren Thorgaard","family":"B\u00f8nl\u00f8kke","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Manuela","family":"Teodorescu","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Hematology Regionshospitalet G\u00f8dstrup  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper N\u00f8rgaard","family":"Strandholdt","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Southwest Jutland  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette Juul","family":"Vangsted","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rigshospitalet Copenhagen University  Copenhagen 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provides update on DREAMM\u20103 phase III trial for Blenrep in relapsed\/refractory multiple myeloma. GSK. Published July 11 2022. 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