{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:21:26Z","timestamp":1785468086035,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this single\u2010center study, we aimed to describe the characteristics, treatment patterns, and outcomes of patients with multiple myeloma (MM) following treatment with bortezomib, carfilzomib, daratumumab, ixazomib, lenalidomide or pomalidomide\u2010based regimens. Data were collected retrospectively from a study cohort of patients receiving a MM treatment in the Hospital District of Helsinki and Uusimaa (HUS) in Finland between 2016\u20132020. In total, 472 patients were included in the study. Median age was 68.2 years and nearly 25% had a high cytogenetic risk according to the International Myeloma Working Group categorization. In 2018\u20132020, the spectrum of regimens used as third\u2010 or later\u2010line therapy was notably broader than in 2016\u20132017. The overall response rates for patients who received the most novel regimens (available \u2264\u00a05 years) in second or third line of therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a067\/430) and fourth line or later (<jats:italic>n<\/jats:italic>\u00a0=\u00a078\/151) were 53.3% and 25.0%, respectively. In this real\u2010world MM patient cohort, the response rates for these novel agents were lower compared to those reported in clinical trials. Given the higher cytogenetic risk profile and more advanced disease stage at the time when treated with novel agents, patients could have benefited from effective novel therapies earlier in their treatment pathway.<\/jats:p><jats:p><jats:list>\n<jats:list-item><jats:p>What is the NEW aspect of your work? (ONE sentence) This study characterized the treatment of Finnish multiple myeloma patients during the era of most novel therapies (after 2016) and also included information on the cytogenetic risk profile of this real\u2010world population.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>What is the CENTRAL finding of your work? (ONE sentence) There are clear differences between real\u2010world populations treated with most novel combinations and those of randomized controlled trials (RCTs), which is reflected by the poorer treatment outcomes in the real\u2010world setting.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>What is (or could be) the SPECIFIC clinical relevance of your work? (ONE sentence) Given the high cytogenetic risk profile and advanced disease stage at the time when treated with novel agents, patients could have benefited from effective novel therapies earlier in their treatment pathway.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/jha2.802","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T18:30:25Z","timestamp":1696789825000},"page":"1019-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world experience of novel multiple myeloma treatments in a large, single\u2010center cohort in Finland"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8603-0415","authenticated-orcid":false,"given":"Heidi","family":"Loponen","sequence":"first","affiliation":[{"name":"MedEngine Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Meht\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"MedEngine Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Ylisaukko\u2010oja","sequence":"additional","affiliation":[{"name":"MedEngine Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Br\u00fcck","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo","family":"Porkka","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perttu","family":"Koskenvesa","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Saukkonen","sequence":"additional","affiliation":[{"name":"Amgen Ab  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Lievonen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"The Finnish Cancer Registry. Statistics and research. 2022. Accessed June 13 2022. Available from:https:\/\/cancerregistry.fi"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04481-4"},{"key":"e_1_2_13_4_1","unstructured":"SEER. Cancer statistics. 2020. Accessed October 8 2020. Available from:https:\/\/seer.cancer.gov\/statfacts\/html\/mulmy.html"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.247"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.11.004"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211019612"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.200"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx096"},{"key":"e_1_2_13_11_1","unstructured":"Finnish Myeloma Group. Treatment guidelines. Accessed October 8 2020. 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