{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:04Z","timestamp":1747149664562,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alleviating symptom burden in patients with myeloproliferative neoplasms (MPNs) is imperative to achieving optimal management. Research remains to elucidate the relationship between the <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic> (<jats:italic>Janus kinase 2<\/jats:italic>) mutation present in many MPN patients, and the symptomatology they experience. This retrospective study analysed data collected from MPN patients included in the Myeloproliferative Neoplasms: An In\u2010depth Case\u2013Control (MOSAICC) pilot study. The MPN Symptom Assessment Form was administered, and median symptom scores were compared between <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic>\u2010positive and <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic>\u2010negative groups. Multivariate logistic regression analysis adjusted for confounding variables. Overall, 106 MPN patients participated: 65.1% were <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic> positive, 30.2% were <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic> negative and 4.7% had an unknown status. Multivariate analysis revealed a low symptom burden for early satiety (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), dizziness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), cough (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and bone pain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) in those receiving venesection alone. Interferon alpha was significantly associated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) with severe burden for 16 of the 27 symptoms. <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic>\u2010positive females experienced a greater symptom burden than <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic>\u2010positive males. There was no discernible relationship between the <jats:italic>JAK2<jats:sub>V617F<\/jats:sub><\/jats:italic> mutation and symptom burden in MPN patients, unlike the therapeutic agents investigated. Larger studies are required to validate these results and identify mechanisms of symptom development and control in MPN patients.<\/jats:p>","DOI":"10.1002\/jha2.805","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:03:16Z","timestamp":1698735796000},"page":"1071-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The <i>JAK2<sub>V617F<\/sub><\/i> mutation and the role of therapeutic agents in alleviating myeloproliferative neoplasm symptom burden"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-4802","authenticated-orcid":false,"given":"Lai Yee","family":"Orbell","sequence":"first","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition University of Aberdeen Aberdeen Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf","family":"Abutheraa","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition University of Aberdeen Aberdeen Scotland UK"},{"name":"Aberdeen Centre for Health Data Science University of Aberdeen Aberdeen Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S","family":"Duncombe","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust, Southampton  England UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Frances","family":"McMullin","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-7972","authenticated-orcid":false,"given":"Ruben","family":"Mesa","sequence":"additional","affiliation":[{"name":"Mays Cancer Center at UT Health San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8609-0788","authenticated-orcid":false,"given":"Charlene M","family":"McShane","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast Belfast Northern Ireland UK"},{"name":"Centre for Public Health Queen's University Belfast Belfast Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"James","sequence":"additional","affiliation":[{"name":"Centre for Public Health Queen's University Belfast Belfast Northern Ireland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-3649","authenticated-orcid":false,"given":"Lesley A","family":"Anderson","sequence":"additional","affiliation":[{"name":"Aberdeen Centre for Health Data Science University of Aberdeen Aberdeen Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0054-y"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23690"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-018-1187-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.69"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.983098"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051113"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-328955"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3082-y"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-577635"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13043"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081901"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0077-1"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000327"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.3.M255"},{"key":"e_1_2_13_16_1","unstructured":"WHO Regional Office for Europe. 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