{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T17:07:09Z","timestamp":1751216829660,"version":"3.40.5"},"reference-count":3,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The simultaneous detection of <jats:italic>BCR<\/jats:italic>::<jats:italic>ABL1<\/jats:italic> and <jats:italic>JAK2<\/jats:italic> V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as <jats:italic>JAK2<\/jats:italic> V617F+ primary myelofibrosis, followed by the emergence of <jats:italic>BCR::ABL1<\/jats:italic>+ chronic myeloid leukemia. The patient then developed <jats:italic>BCR::ABL1+<\/jats:italic> B\u2010lymphoblastic leukemia. Treatment for B\u2010lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case.<\/jats:p>","DOI":"10.1002\/jha2.806","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:04:20Z","timestamp":1704956660000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From primary myelofibrosis to chronic myeloid leukemia, <i>BCR::ABL1<\/i>+ B\u2010Lymphoblastic leukemia, and back to primary myelofibrosis: An illustration of dynamic clonal evolution"],"prefix":"10.1002","volume":"5","author":[{"given":"Devin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-6097","authenticated-orcid":false,"given":"Wataru","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-8068","authenticated-orcid":false,"given":"M. James","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.182"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000129"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0300-1652.149177"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:49:17Z","timestamp":1708706957000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jha2.806"],"URL":"https:\/\/doi.org\/10.1002\/jha2.806","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}