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The Centers for Disease Control and Prevention have classified sickle cell disease (SCD) as a condition that increases the risk of severe illness from COVID\u201019 infection.<\/jats:p><jats:p>A retrospective study was conducted using the TRiNetX health research network database to identify SCA patients ( HbSS, Sbeta\u2010thalassemia zero) who had SARS\u2010CoV\u20102 infection over 2 years; these were compared with similar patients who did not have the infection in terms of demographics, pain control, and laboratory parameters<\/jats:p><jats:p>COVID\u201019 illness impacts [ain crises and ACS, and prior vaccination against influenza and COVID\u201019 may represent a protective factor for developing pain crises.<\/jats:p>","DOI":"10.1002\/jha2.840","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T01:39:56Z","timestamp":1709257196000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of SARS\u2010CoV\u20102 infection on pain crisis and acute chest syndrome in patients with sickle cell anemia: A retrospective multi\u2010cohort study based on US national data from 2020 to 2022"],"prefix":"10.1002","volume":"5","author":[{"given":"Juan","family":"Alvarado","sequence":"first","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keval","family":"Yerigeri","sequence":"additional","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Boakye","sequence":"additional","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Randolph","sequence":"additional","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Roy","sequence":"additional","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-4151","authenticated-orcid":false,"given":"Grace","family":"Onimoe","sequence":"additional","affiliation":[{"name":"MetroHealth Medical System  Cleveland Ohio USA"},{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"issue":"7","key":"e_1_2_11_2_1","first-page":"831","article-title":"Inflammation in COVID\u201019: from pathogenesis to treatment","volume":"14","author":"Wong RSY","year":"2021","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.19759"},{"key":"e_1_2_11_4_1","unstructured":"KarpmanM ZuckermanS GonzalezD KenneyGM.The COVID\u201019 pandemic is straining families\u2019 abilities to afford basic needs [Internet].2020. 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