{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:08:06Z","timestamp":1788520086868,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BRAF mutations are associated with a small number of hematologic malignancies, including hairy cell leukemia and histiocytic disorders. In addition, BRAF mutations have also been detected in low frequency in other B\u2010cell lymphomas, such as chronic lymphocytic leukemia and diffuse large B\u2010cell lymphoma, but never in mantle cell lymphoma (MCL). We present a case of a 69\u2010year\u2010old female with classic MCL harboring a BRAF<jats:sup>N581S<\/jats:sup> mutation. To our knowledge, this is the first reported case of any BRAF mutation in MCL.<\/jats:p>","DOI":"10.1002\/jha2.847","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T11:56:37Z","timestamp":1705492597000},"page":"247-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel BRAF N581S mutation in mantle cell lymphoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Nisha","family":"Hariharan","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davsheen","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010You","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-0861","authenticated-orcid":false,"given":"Benjamin M.","family":"Heyman","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"253","article-title":"BRAF mutation in hairy cell leukemia","volume":"8","author":"Ahmadzadeh A","year":"2014","journal-title":"Oncol Rev"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-418434"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130977"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.695777"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0082-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.742525"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.196931"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0215-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1615"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11882"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.06.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506583"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5029"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-635326"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:49:31Z","timestamp":1708706971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jha2.847"],"URL":"https:\/\/doi.org\/10.1002\/jha2.847","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}