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We report the case of patient with severe anaphylaxis with cardiac arrest after tisagenlecleucel injection for Diffuse Large B cell Lymphoma, who recovered after resuscitation and intensive care treatment; we also conducted a Food and Drug Administration Adverse Event Reporting System database analysis and found several cases of severe anaphlyaxis after CAR\u2010T cell injection. Although not reported in pivotal CAR\u2010T cell studies, anaphylaxis can occur after CAR\u2010T cell injection, highlighting the need to include anaphylaxis as a possible side effect in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.874","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:49:20Z","timestamp":1713592160000},"page":"603-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe anaphylaxis after chimeric antigen receptor T\u2010cell injection: a case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5740-2035","authenticated-orcid":false,"given":"Sarah","family":"Morin","sequence":"first","affiliation":[{"name":"Department of Oncology Division of Hematology Geneva University Hospitals  Geneva Switzerland"},{"name":"Department of Medicine Faculty of Medicine Translational Research Center for Oncohematology 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